Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | NAT1 | P18440 | 1/20 | 0.54 |
| ▸ | ALPL | P05186 | 1/20 | 0.53 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10708397 | 0.81 | MEN1 (0.74) | NPC1NAT1ALPLALPIKMT2A | |
| SCHEMBL10708392 | 0.81 | MEN1 (0.74) | NPC1NAT1ALPLALPIKMT2A | |
| SCHEMBL9255652 | 0.78 | MMP2 (0.64) | NPC1NAT1ALPLALPIKMT2A | |
| SCHEMBL9255656 | 0.78 | MMP2 (0.64) | NPC1NAT1ALPLALPIKMT2A | |
| SCHEMBL14586372 | 0.75 | NPC1 (0.68) | NPC1NAT1KMT2AGAAALDH1A1 | |
| SCHEMBL9277804 | 0.75 | ALDH1A1 (0.61) | NPC1NAT1ALPLALPIKMT2A | |
| SCHEMBL9353117 | 0.75 | ALDH1A1 (0.61) | NPC1NAT1ALPLALPIKMT2A | |
| SCHEMBL6674966 | 0.75 | POLB (0.55) | ALPIKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL6775654 | 0.74 | KMT2A (0.50) | NPC1NAT1ALPLALPIKMT2A | |
| SCHEMBL4040479 | 0.73 | NPC1 (0.65) | NPC1NAT1KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200400-B1 | SUBSTITUTED PYRROLIDIN-2,3,4-TRION DERIVATIVES USEFUL AS NMDA-RECEPTOR ANTAGONISTS | GRUENENTHAL GMBH (DE) | 2004-09-29 | — | — | EP | claimed |