Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CHIT1 | Q13231 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6675971 | 0.89 | CACNA1C (0.43) | CACNA1CSCN5AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL6674712 | 0.84 | ALDH1A1 (0.36) | LMNAPOLBALDH1A1HTTMAPT | |
| SCHEMBL6677282 | 0.80 | POLB (0.34) | CACNA1CSCN5ALMNAPOLBALDH1A1 | |
| SCHEMBL6675327 | 0.80 | CACNA1C (0.45) | CACNA1CSCN5AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL6676761 | 0.79 | POLB (0.35) | CACNA1CSCN5ALMNAPOLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL6679167 | 0.78 | CACNA1C (0.44) | CACNA1CSCN5AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL6678030 | 0.78 | SIGMAR1 (0.44) | CACNA1CSCN5AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL6677280 | 0.78 | LMNA (0.34) | LMNAPOLBALDH1A1HTTHSD17B10 | |
| SCHEMBL6676005 | 0.76 | LMNA (0.33) | LMNAPOLBALDH1A1HTTMAPT | |
| SCHEMBL6676424 | 0.75 | CACNA1C (0.48) | CACNA1CSCN5AGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |