Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLI1 | P08151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6675819 | 0.88 | TAAR1 (0.37) | MEN1KMT2ATRPA1SLC6A2SLC6A4 | |
| SCHEMBL6681753 | 0.88 | TAAR1 (0.37) | MEN1KMT2ATRPA1SLC6A2SLC6A4 | |
| SCHEMBL6678803 | 0.88 | OPRM1 (0.40) | TRPA1SLC6A2SLC6A4OPRM1OPRD1 | |
| SCHEMBL6941045 | 0.84 | TRPA1 (0.36) | MEN1KMT2ATRPA1SLC6A2SLC6A4 | |
| SCHEMBL6676478 | 0.84 | SLC18A3 (0.40) | LMNAOPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL7737765 | 0.83 | SLC18A3 (0.39) | LMNAOPRM1OPRD1OPRK1 | |
| SCHEMBL6681591 | 0.82 | KCNQ2 (0.38) | MEN1KMT2ATRPA1SLC6A2SLC6A4 | |
| SCHEMBL6936768 | 0.81 | SLC6A9 (0.39) | MEN1KMT2ALMNAPOLBTDP1 | |
| Hydrochloric Acid SCHEMBL7741185 | 0.80 | OPRL1 (0.39) | MEN1KMT2ALMNAPOLBTDP1 | |
| SCHEMBL5846181 | 0.79 | ALDH1A1 (0.38) | MEN1KMT2ATRPA1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289514-B1 | USE OF SUBSTITUTED 1-AMINO-5-PHENYLPENTANE-3-OL AND/OR 1-AMINO-6-PHENYLHEXANE-3-OL COMPOUNDS AS MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2004-11-03 | — | — | EP | claimed |
| US-6784175-B2 | WITH AN N-METHYL-D-ASPARTATE (NMDA) ANTAGONISTIC EFFECT | GRUENENTHAL GMBH (DE) | 2004-08-31 | — | — | US | claimed |
| US-20030181450-A1 | Use of substituted 1-amino-5-phenylpentane-3-ol and/or 1-amino-6-phenylhexane-3-ol compounds as medicaments | GRUENENTHAL GMBH (DE) | 2003-09-25 | — | — | US | claimed |
| EP-1289514-A1 | USE OF SUBSTITUTED 1-AMINO-5-PHENYLPENTANE-3-OL AND/OR 1-AMINO-6-PHENYLHEXANE-3-OL COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2003-03-12 | — | — | EP | claimed |
| WO-2001089505-A1 | USE OF SUBSTITUTED 1-AMINO-5-PHENYLPENTANE-3-OL AND/OR 1-AMINO-6-PHENYLHEXANE-3-OL COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2001-11-29 | — | — | WO | claimed |
| EP-1289514-B1 | USE OF SUBSTITUTED 1-AMINO-5-PHENYLPENTANE-3-OL AND/OR 1-AMINO-6-PHENYLHEXANE-3-OL COMPOUNDS AS MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2004-11-03 | — | — | EP | disclosed |
| US-6784175-B2 | WITH AN N-METHYL-D-ASPARTATE (NMDA) ANTAGONISTIC EFFECT | GRUENENTHAL GMBH (DE) | 2004-08-31 | — | — | US | disclosed |
| US-20030181450-A1 | Use of substituted 1-amino-5-phenylpentane-3-ol and/or 1-amino-6-phenylhexane-3-ol compounds as medicaments | GRUENENTHAL GMBH (DE) | 2003-09-25 | — | — | US | disclosed |
| EP-1289514-A1 | USE OF SUBSTITUTED 1-AMINO-5-PHENYLPENTANE-3-OL AND/OR 1-AMINO-6-PHENYLHEXANE-3-OL COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001089505-A1 | USE OF SUBSTITUTED 1-AMINO-5-PHENYLPENTANE-3-OL AND/OR 1-AMINO-6-PHENYLHEXANE-3-OL COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181450-A1 | Use of substituted 1-amino-5-phenylpentane-3-ol and/or 1-amino-6-phenylhexane-3-ol compounds as medicaments | GRIN3A, GRIN1, GRIN3B | MEN1 1994/4885KMT2A 1594/4885LMNA 4722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.