Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5846854 | 0.99 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2AMAPK1SIGMAR1 | |
| SCHEMBL6940278 | 0.90 | SIGMAR1 (0.36) | ALDH1A1MEN1KMT2ASIGMAR1TRPA1 | |
| SCHEMBL6681753 | 0.88 | TAAR1 (0.37) | ALDH1A1MEN1KMT2AMAPK1SIGMAR1 | |
| SCHEMBL6937419 | 0.88 | P2RX7 (0.39) | KMT2ATRPA1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL5846320 | 0.86 | SLC6A4 (0.36) | MEN1KMT2ATRPA1SLC6A4SLC6A2 | |
| SCHEMBL6941995 | 0.86 | ESR1 (0.37) | ALDH1A1MEN1KMT2AMAPK1TRPA1 | |
| SCHEMBL6937028 | 0.86 | TRPA1 (0.38) | ALDH1A1MEN1KMT2ATRPA1SLC6A4 | |
| SCHEMBL6936768 | 0.85 | SLC6A9 (0.39) | MEN1KMT2ATRPA1SLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL5847568 | 0.85 | SLC6A4 (0.36) | MEN1KMT2ATRPA1SLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL7741185 | 0.84 | OPRL1 (0.39) | MEN1KMT2ATRPA1SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7012099-B2 | Using substituted 4-amino-1- phenylbutan-2-ol compounds in form of their racemates, enantiomers, diastereoisomers or corresponding bases or corresponding salts of acids as regulators for the nociceptin/orphanin FQ ligands in drugs | GRUENENTHAL GMBH (DE) | 2006-03-14 | — | — | US | claimed |
| EP-1253917-B1 | USE OF SUBSTITUTED 4-AMINO-1-PHENYLBUTAN-2-OL COMPOUNDS AS MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2005-02-16 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-20030008859-A1 | Use of substituted 4-amino-1-phenylbutan-2-ol compounds as medicaments | GRUENENTHAL GMBH (DE) | 2003-01-09 | — | — | US | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| US-7012099-B2 | Using substituted 4-amino-1- phenylbutan-2-ol compounds in form of their racemates, enantiomers, diastereoisomers or corresponding bases or corresponding salts of acids as regulators for the nociceptin/orphanin FQ ligands in drugs | GRUENENTHAL GMBH (DE) | 2006-03-14 | — | — | US | disclosed |
| US-20030008859-A1 | Use of substituted 4-amino-1-phenylbutan-2-ol compounds as medicaments | GRUENENTHAL GMBH (DE) | 2003-01-09 | — | — | US | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030008859-A1 | Use of substituted 4-amino-1-phenylbutan-2-ol compounds as medicaments | OPRL1, OPRM1, OPRK1 | ALDH1A1 659/4885MEN1 4745/4885KMT2A 4506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.