Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.66 |
| ▸ | RAB9A | P51151 | 6/20 | 0.66 |
| ▸ | HTT | P42858 | 5/20 | 0.66 |
| ▸ | NPC1 | O15118 | 4/20 | 0.66 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.52 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.52 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7759976 | 0.84 | MEN1 (0.68) | SMN1; SMN2RAB9AHTTNPC1GRIK1 | |
| SCHEMBL28772738 | 0.81 | KIF11 (0.48) | SMN1; SMN2RAB9AHTTNPC1GRIK1 | |
| SCHEMBL9744243 | 0.80 | GRIK1 (0.71) | SMN1; SMN2RAB9AHTTNPC1GRIK1 | |
| SCHEMBL17609477 | 0.80 | RAB9A (1.00) | SMN1; SMN2RAB9AHTTNPC1MEN1 | |
| SCHEMBL5595167 | 0.78 | SMN1; SMN2 (0.74) | SMN1; SMN2RAB9AHTTNPC1MEN1 | |
| SCHEMBL6823516 | 0.78 | SMN1; SMN2 (0.74) | SMN1; SMN2RAB9AHTTNPC1MEN1 | |
| SCHEMBL11251374 | 0.78 | MEN1 (0.57) | SMN1; SMN2RAB9AHTTNPC1GRIK1 | |
| SCHEMBL20560306 | 0.78 | ALOX15 (0.46) | SMN1; SMN2RAB9AHTTGRIK1MEN1 | |
| SCHEMBL4117684 | 0.77 | EPHX2 (0.55) | SMN1; SMN2RAB9AHTTNPC1GRIK1 | |
| SCHEMBL6439621 | 0.77 | GRIK1 (0.63) | SMN1; SMN2RAB9AHTTNPC1GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472233-A1 | PYRIMIDINE COMPOUNDS | SmithKline Beecham Corporation (US) | 2004-11-03 | — | — | EP | claimed |
| WO-2003066601-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-08-14 | — | — | WO | claimed |