Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | APOB | P04114 | 3/20 | 0.36 |
| ▸ | MTTP | P55157 | 3/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677620 | 0.92 | APOB (0.41) | TACR1KDRACACBJAK2JAK3 | |
| SCHEMBL6688287 | 0.85 | PRMT5 (0.38) | TACR1KDRACACBDGAT2MAPT | |
| SCHEMBL7041135 | 0.82 | SMO (0.52) | KDRMAPTLMNASMN1; SMN2APOB | |
| SCHEMBL6966580 | 0.80 | SCN9A (0.43) | TACR1KDRJAK2JAK3PTK2 | |
| SCHEMBL6973499 | 0.79 | SMO (0.45) | KDRACACBJAK2JAK3PTK2 | |
| SCHEMBL6974835 | 0.79 | ABCB1 (0.48) | ACACBMAPTLMNASMN1; SMN2APOB | |
| SCHEMBL6967435 | 0.78 | APOB (0.41) | ACACBJAK2JAK3PTK2MAPT | |
| SCHEMBL6974297 | 0.77 | CACNA1G (0.51) | KDRJAK2JAK3PTK2APOB | |
| SCHEMBL6964489 | 0.77 | SMO (0.50) | APOBMTTPSRPK1 | |
| SCHEMBL6974444 | 0.76 | KDM4E (0.44) | ACACBJAK2JAK3PTK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902785-B1 | PROCESSES AND INTERMEDIATES FOR PREPARING 4'-TRIFLUOROMETHYLBIPHENYL-2-CARBOXYLIC ACID 2-(2H- 1,2,4]TRIAZOL-3-YLMETHYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-YL]-AMIDE | PFIZER (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1192142-A1 | CYCLO-IMINO DEPSIPEPTIDES AND THEIR UTILIZATION IN CONTROLLING ENDOPARASITES | Bayer Aktiengesellschaft (DE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076985-A1 | CYCLO-IMINO DEPSIPEPTIDES AND THEIR UTILIZATION IN CONTROLLING ENDOPARASITES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-12-21 | — | — | WO | disclosed |
| EP-0902785-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING 4'-TRIFLUOROMETHYLBIPHENYL-2-CARBOXYLIC ACID 2-(2H- 1,2,4]TRIAZOL-3-YLMETHYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-YL]-AMIDE | PFIZER INC. (US) | 1999-03-24 | — | — | EP | disclosed |