Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 3/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16394743 | 0.87 | ALDH1A1 (0.42) | TAS2R14ALDH1A1HPGDDHODHPLK1 | |
| SCHEMBL28636307 | 0.85 | ALDH1A1 (0.45) | ALDH1A1HPGDPLK1AKR1C3AKR1C2 | |
| SCHEMBL6636838 | 0.80 | ALDH1A1 (0.39) | ALDH1A1HPGDPLK1AKR1C3AKR1C2 | |
| SCHEMBL27843612 | 0.79 | HSD11B1 (0.44) | TAS2R14PLK1AKR1C3AKR1C2PDCD1 | |
| SCHEMBL29702020 | 0.79 | ALDH1A1 (0.43) | ALDH1A1HPGDPLK1AKR1C3AKR1C2 | |
| SCHEMBL344492 | 0.78 | ALDH1A1 (0.49) | TAS2R14ALDH1A1HPGDPLK1FOLH1 | |
| SCHEMBL1775363 | 0.78 | ESR2 (0.44) | ALDH1A1DHODHPDCD1CD274TSHR | |
| SCHEMBL29188682 | 0.77 | ALDH1A1 (0.42) | ALDH1A1HPGDPLK1AKR1C3AKR1C2 | |
| SCHEMBL27489890 | 0.76 | ALDH1A1 (0.46) | ALDH1A1DHODHAKR1C3AKR1C2TSHR | |
| SCHEMBL22208710 | 0.76 | TAS2R14 (0.42) | TAS2R14ALDH1A1HPGDDHODHKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472226-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003045921-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |