Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 16/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6683660 | 0.86 | S1PR1 (0.48) | S1PR1S1PR3LMNA | |
| SCHEMBL6677363 | 0.83 | NPC1 (0.48) | POLBS1PR1S1PR3MAPTLMNA | |
| SCHEMBL6682444 | 0.80 | TLR8 (0.47) | POLBGAAALDH1A1MAPTHPGD | |
| SCHEMBL6677407 | 0.80 | MAPT (0.51) | POLBGAAS1PR1S1PR3ALDH1A1 | |
| SCHEMBL6677053 | 0.78 | ITGB1 (0.44) | POLBGAAS1PR1S1PR3MAPT | |
| SCHEMBL6501138 | 0.76 | MAPT (0.44) | POLBGAAS1PR1S1PR3MAPT | |
| SCHEMBL6682828 | 0.75 | S1PR1 (0.46) | S1PR1S1PR3 | |
| SCHEMBL6679699 | 0.75 | S1PR1 (0.43) | S1PR1S1PR3 | |
| SCHEMBL6640573 | 0.75 | LMNA (0.52) | POLBS1PR1S1PR3ALDH1A1MAPT | |
| SCHEMBL6685612 | 0.75 | S1PR1 (0.46) | GAAS1PR1S1PR3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472226-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003045921-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |