SCHEMBL6678488

SCHEMBL6678488

O=C(Nc1nc(C(F)(F)F)c(I)s1)c1c(Cl)cccc1Cl

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.49
KMT2A Q03164 6/20 0.49
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
TYK2 P29597 2/20 0.47
GRM4 Q14833 3/20 0.45
L3MBTL1 Q9Y468 1/20 0.43
JAK2 O60674 1/20 0.43
CYP3A4 P08684 1/20 0.43
JAK1 P23458 1/20 0.43
MAPT P10636 2/20 0.42
NPSR1 Q6W5P4 2/20 0.42
ALDH1A1 P00352 1/20 0.42
TLR7 Q9NYK1 1/20 0.41
RXFP1 Q9HBX9 2/20 0.41
PRNP P04156 1/20 0.41
PTGES O14684 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.39
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6680901 0.80 CASP3 (0.54) MEN1KMT2ANPC1RAB9ACYP3A4
SCHEMBL7240089 0.78 P2RX1 (0.53) MEN1KMT2ANPC1RAB9AMAPT
SCHEMBL6677807 0.77 TRPV1 (0.51) MEN1KMT2ANPC1RAB9A
SCHEMBL20481571 0.74 TP53 (0.36) MEN1KMT2ANPC1RAB9AGRM4
SCHEMBL6683045 0.74 PI4KB (0.45) MAPTRXFP1
SCHEMBL20481567 0.72 ALDH1A1 (0.35) MEN1KMT2ANPC1RAB9AGRM4
SCHEMBL8517713 0.70 ALDH1A1 (0.39) L3MBTL1MAPTALDH1A1RXFP1SMN1; SMN2
SCHEMBL4915916 0.70 RAB9A (0.83) MEN1KMT2ANPC1RAB9AALDH1A1
SCHEMBL11397081 0.70 RXFP1 (0.65) MEN1KMT2ANPC1RAB9ANPSR1
SCHEMBL9080721 0.69 KMT2A (0.46) MEN1KMT2ATYK2JAK2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004056177-A2 INSECTICIDAL AMINOTHIAZOLE DERIVATIVES NIPPON SODA CO. LTD. (JP) 2004-07-08 WO disclosed
US-6737382-B1 WIDE SPECTRUM OF PLANT PROTECTING ACTIVITY NIPPON SODA CO. LTD. (JP) 2004-05-18 US disclosed
US-20040082629-A1 INSECTICIDAL AMINOTHIAZOLE DERIVATIVES NIPPON SODA CO., LTD. 2004-04-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040082629-A1 INSECTICIDAL AMINOTHIAZOLE DERIVATIVES SCN7A, SCN2B, CASP7 MEN1 4500/4885KMT2A 1863/4885NPC1 1168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.