Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | CTSA | P10619 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL71034 | 0.82 | HIF1A (0.55) | HIF1ACTSA | |
| SCHEMBL29929320 | 0.82 | HIF1A (0.55) | HIF1ACTSA | |
| Hydrochloric Acid SCHEMBL28470042 | 0.81 | HIF1A (0.54) | HIF1ACTSA | |
| SCHEMBL11047806 | 0.79 | HIF1A (0.53) | HIF1AEGLN1CTSAMEN1KMT2A | |
| SCHEMBL6264166 | 0.79 | MAPT (0.53) | HIF1AEGLN1CTSAMEN1KMT2A | |
| Ethylene SCHEMBL29031104 | 0.79 | HIF1A (0.53) | HIF1ACTSA | |
| SCHEMBL2554720 | 0.79 | HIF1A (0.56) | HIF1AEGLN1CTSAMEN1KMT2A | |
| SCHEMBL2927582 | 0.79 | HIF1A (0.53) | HIF1AKMT2A | |
| SCHEMBL12723128 | 0.76 | HIF1A (0.61) | HIF1AEGLN1CTSAUSP30 | |
| SCHEMBL14897984 | 0.76 | HIF1A (0.50) | HIF1AEGLN1CTSAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004043974-A1 | PRODUCTION OF IRIDIUM COMPLEXES | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2004-05-27 | — | — | WO | disclosed |