Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CES2 | O00748 | 3/20 | 0.45 |
| ▸ | CES1 | P23141 | 3/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720153 | 0.91 | AKT1 (0.52) | AKT1LMNATDP1L3MBTL1ALDH1A1 | |
| SCHEMBL5369406 | 0.84 | LMNA (0.49) | AKT1LMNATDP1L3MBTL1ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL9507417 | 0.82 | LMNA (0.47) | AKT1LMNATDP1L3MBTL1ALDH1A1 | |
| SCHEMBL11287380 | 0.78 | LMNA (0.54) | AKT1LMNATDP1L3MBTL1ALDH1A1 | |
| SCHEMBL27624213 | 0.77 | MEN1 (0.51) | LMNATDP1ALDH1A1TSHRPGR | |
| SCHEMBL45241 | 0.77 | LMNA (0.52) | AKT1LMNATDP1L3MBTL1ALDH1A1 | |
| SCHEMBL28060783 | 0.76 | TDP1 (0.52) | AKT1LMNATDP1L3MBTL1ALDH1A1 | |
| SCHEMBL9093296 | 0.75 | LMNA (0.51) | AKT1LMNATDP1L3MBTL1ALDH1A1 | |
| SCHEMBL45332 | 0.75 | AKT1 (0.48) | AKT1LMNATDP1L3MBTL1ALDH1A1 | |
| SCHEMBL8978421 | 0.75 | AKT1 (0.48) | AKT1LMNATDP1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476433-A1 | NOVEL TRICYCLOIMIDAZOLINE DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | PIERRE FABRE MEDICAMENT (FR) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003068755-A1 | NOVEL TRICYCLOIMIDAZOLINE DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | PIERRE FABRE MEDICAMENT (FR) | 2003-08-21 | — | — | WO | disclosed |