SCHEMBL6679281

SCHEMBL6679281

O=C(Nc1nc(C(F)(F)F)c(Br)s1)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 1/20 0.50
TAS1R1 Q7RTX1 1/20 0.50
TAS1R2 Q8TE23 1/20 0.50
RIPK1 Q13546 1/20 0.48
STAT3 P40763 1/20 0.47
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
KDM4E B2RXH2 1/20 0.46
MAPT P10636 1/20 0.46
PKM P14618 1/20 0.46
PIK3CD O00329 1/20 0.45
PIK3C2B O00750 1/20 0.45
AURKA O14965 1/20 0.45
PIK3C2G O75747 1/20 0.45
CDK1 P06493 1/20 0.45
CDK4 P11802 1/20 0.45
CCND1 P24385 1/20 0.45
CDK2 P24941 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2593847 0.75 GRM4 (0.58) RIPK1MEN1KMT2ANPC1RAB9A
SCHEMBL6679100 0.74 KMT2A (0.53) STAT3MEN1KMT2AKDM4EMAPT
SCHEMBL15427029 0.74 TAS1R3 (0.59) TAS1R3TAS1R1TAS1R2MEN1KMT2A
SCHEMBL330403 0.73 TMPRSS4 (0.55) RIPK1MAPT
SCHEMBL6680361 0.72 RAB9A (0.55) RIPK1MEN1KMT2ANPC1RAB9A
SCHEMBL18230235 0.72 ADORA3 (0.62) TAS1R3TAS1R1TAS1R2STAT3KMT2A
SCHEMBL7239127 0.72 GRM5 (0.54) STAT3MEN1KMT2ANPC1KDM4E
SCHEMBL4917465 0.71 TOP1 (0.70) MEN1KMT2ANPC1RAB9AKDM4E
SCHEMBL4188640 0.70 NPC1 (0.60) MEN1KMT2ANPC1RAB9AKDM4E
SCHEMBL7247155 0.70 RIPK1 (0.40) RIPK1MEN1KMT2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004056177-A2 INSECTICIDAL AMINOTHIAZOLE DERIVATIVES NIPPON SODA CO. LTD. (JP) 2004-07-08 WO disclosed
US-6737382-B1 WIDE SPECTRUM OF PLANT PROTECTING ACTIVITY NIPPON SODA CO. LTD. (JP) 2004-05-18 US disclosed
US-20040082629-A1 INSECTICIDAL AMINOTHIAZOLE DERIVATIVES NIPPON SODA CO., LTD. 2004-04-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040082629-A1 INSECTICIDAL AMINOTHIAZOLE DERIVATIVES SCN7A, SCN2B, CASP7 TAS1R3 310/4885TAS1R1 334/4885TAS1R2 467/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.