Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726583 | 0.82 | SMN1; SMN2 (0.39) | POLBKDM4EMEN1GAAMAPT | |
| SCHEMBL9733 | 0.79 | MEN1 (0.37) | POLBKDM4EMEN1GAAMAPT | |
| SCHEMBL1728693 | 0.78 | KDM4E (0.38) | POLBKDM4EMEN1GAAMAPT | |
| SCHEMBL8073 | 0.76 | KMT2A (0.36) | POLBKDM4EMEN1GAAMAPT | |
| SCHEMBL12014770 | 0.73 | NQO2 (0.46) | POLBKDM4EMEN1MAPTKMT2A | |
| SCHEMBL28455249 | 0.71 | GAA (0.50) | POLBKDM4EMEN1GAAMAPT | |
| SCHEMBL10751843 | 0.70 | HSP90AA1 (0.63) | POLBKDM4EMEN1GAAMAPT | |
| SCHEMBL4191610 | 0.70 | MAOB (0.40) | POLBKDM4EMEN1GAAMAPT | |
| SCHEMBL9952093 | 0.70 | KDM4E (0.51) | POLBKDM4EMEN1GAAMAPT | |
| SCHEMBL14047560 | 0.70 | DRD4 (0.44) | KDM4EMEN1GAAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058112-A1 | FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2011-05-19 | — | — | WO | disclosed |