Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 5/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6623867 | 0.89 | PDPK1 (0.49) | LRRK2CA2CA9ENPP3CA1 | |
| SCHEMBL27997605 | 0.89 | CA2 (0.43) | LRRK2CA2CA9ENPP3CA1 | |
| SCHEMBL6624142 | 0.87 | CA2 (0.44) | LRRK2CA2CA9ENPP3IKBKB | |
| SCHEMBL20899926 | 0.83 | CA2 (0.45) | CA2CA9ENPP3CA1CA12 | |
| SCHEMBL20899969 | 0.78 | CA2 (0.51) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL6681646 | 0.76 | GABRA1 (0.41) | LRRK2CA2CA9ENPP3IKBKB | |
| SCHEMBL31345785 | 0.75 | LOXL2 (0.56) | CA2CA9ENPP3CA1CA12 | |
| SCHEMBL5693321 | 0.74 | CA2 (0.41) | LRRK2CA2CA9ENPP3CA1 | |
| SCHEMBL27944286 | 0.73 | CA2 (0.55) | CA2CA9ENPP3CA1CA12 | |
| Hydrochloric Acid SCHEMBL20899879 | 0.73 | CA2 (0.40) | LRRK2CA2CA9ENPP3CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003043999-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-05-30 | — | — | WO | disclosed |