Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6623864 | 0.89 | PDPK1 (0.49) | ENPP3CA2CA9CHEK2LRRK2 | |
| SCHEMBL28816427 | 0.89 | LOXL2 (0.45) | ENPP3CA2CA9CHEK2LRRK2 | |
| SCHEMBL6624144 | 0.88 | PTPRC (0.43) | ENPP3CA2CA9CHEK2IKBKB | |
| SCHEMBL20899928 | 0.84 | SLC6A11 (0.42) | ENPP3CA2CA9CHEK2LOXL2 | |
| SCHEMBL30130504 | 0.80 | ALDH1A1 (0.39) | ENPP3CA2CA9CHEK2ADORA2A | |
| SCHEMBL3838065 | 0.80 | ALDH1A1 (0.39) | ENPP3CA2CA9CHEK2ADORA2A | |
| SCHEMBL20899966 | 0.78 | CA2 (0.43) | ENPP3CA2CA9ADORA1 | |
| SCHEMBL6681642 | 0.76 | LRRK2 (0.44) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL29608350 | 0.75 | ADORA2A (0.47) | ENPP3CA2CA9ADORA2AADORA1 | |
| SCHEMBL1093747 | 0.75 | ADORA2A (0.47) | ENPP3CA2CA9ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003043999-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-05-30 | — | — | WO | disclosed |