Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677902 | 0.83 | MEN1 (0.47) | MEN1KMT2AHTTCYP3A4TSHR | |
| SCHEMBL6678138 | 0.77 | MEN1 (0.45) | MEN1KMT2AHTTCYP3A4TSHR | |
| SCHEMBL6681184 | 0.76 | MEN1 (0.38) | MEN1KMT2AHTTCYP3A4TSHR | |
| SCHEMBL28890126 | 0.65 | AKR1C1 (0.46) | KMT2AHTTTSHRALDH1A1LMNA | |
| SCHEMBL830804 | 0.65 | MEN1 (0.53) | MEN1KMT2AHTTTSHRADAM17 | |
| SCHEMBL6679652 | 0.65 | CES2 (0.36) | MEN1KMT2AHTTTSHRALDH1A1 | |
| SCHEMBL349195 | 0.64 | MEN1 (0.56) | MEN1KMT2AHTT | |
| SCHEMBL6677414 | 0.64 | KMT2A (0.40) | MEN1KMT2AHTTCYP3A4TSHR | |
| SCHEMBL6677071 | 0.62 | SMN1; SMN2 (0.36) | MEN1KMT2AALDH1A1SIGMAR1HSD17B10 | |
| SCHEMBL6677394 | 0.62 | AKR1C1 (0.37) | MEN1KMT2AHTTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472226-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003045921-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |