Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | IFNAR1 | P17181 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580069 | 0.82 | LIPG (0.33) | LIPG | |
| SCHEMBL3229542 | 0.81 | ALDH1A1 (0.33) | ALDH1A1LIPG | |
| SCHEMBL14645439 | 0.79 | KDM4E (0.37) | ALDH1A1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL9274789 | 0.78 | TSHR (0.36) | SLC6A4HTR2ASLC6A2SLC6A3CYP3A4 | |
| SCHEMBL3521758 | 0.77 | KDM4E (0.34) | ALDH1A1POLBKDM4EMAPT | |
| SCHEMBL5899432 | 0.76 | TSHR (0.36) | ALDH1A1POLBKDM4ECYP3A4MAPT | |
| SCHEMBL30949224 | 0.75 | LIPG (0.50) | SLC6A4HTR2AMCL1ALDH1A1PKM | |
| SCHEMBL30949223 | 0.75 | LIPG (0.50) | SLC6A4HTR2AMCL1ALDH1A1PKM | |
| SCHEMBL902105 | 0.75 | LIPG (0.50) | SLC6A4HTR2AMCL1ALDH1A1PKM | |
| SCHEMBL22684752 | 0.74 | ENPP2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE48547-E1 | Aminopyrimidinecarboxamides as CXCR2 modulators | SYNTRIX BIOSYSTEMS INC. (US) | 2021-05-11 | — | — | US | disclosed |
| EP-2608672-B1 | AMINOPYRIDINE- AND AMINOPYRIMIDINECARBOXAMIDES AS CXCR2 MODULATORS | SYNTRIX BIOSYSTEMS INC (US) | 2020-12-16 | — | — | EP | disclosed |
| US-RE47740-E1 | Aminopyridinecarboxamides as CXCR2 modulators | SYNTRIX BIOSYSTEMS INC. (US) | 2019-11-26 | — | — | US | disclosed |
| US-8993541-B2 | Aminopyrimidinecarboxamides as CXCR2 modulators | SYNTRIX BIOSYSTEMS, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140256678-A1 | Aminopyrimidinecarboxamides as CXCR2 Modulators | SYNTRIX BIOSYSTEMS, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| US-8779149-B2 | Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators | SYNTRIX BIOSYSTEMS, INC. (US) | 2014-07-15 | — | — | US | disclosed |
| EP-2608672-A1 | AMINOPYRIDINE- AND AMINOPYRIMIDINECARBOXAMIDES AS CXCR2 MODULATORS | Syntrix Biosystems, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027289-A1 | AMINOPYRIDINE- AND AMINOPYRIMIDINECARBOXAMIDES AS CXCR2 MODULATORS | SYNTRIX BIOSYSTEMS INC. (US) | 2012-03-01 | — | — | WO | disclosed |
| US-20120046243-A1 | Aminopyridine- and Aminopyrimidinecarboxamides as CXCR2 Modulators | SYNTRIX BIOSYSTEMS INC. (US) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256678-A1 | Aminopyrimidinecarboxamides as CXCR2 Modulators | CXCR2, CXCR5, CXCR3 | SLC6A4 3684/4885HTR2A 982/4885MCL1 796/4885 |
| US-20120046243-A1 | Aminopyridine- and Aminopyrimidinecarboxamides as CXCR2 Modulators | CXCR2, CXCR5, CXCR3 | SLC6A4 2997/4885HTR2A 599/4885MCL1 1198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.