Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4557709 | 0.74 | ALDH1A1 (0.44) | LMNACYP19A1HTTP2RX7MAPK1 | |
| SCHEMBL27494778 | 0.73 | SLC6A3 (0.35) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3421581 | 0.73 | CHRM1 (0.35) | POLBSMN1; SMN2ALDH1A1CHRM1CYP2C9 | |
| SCHEMBL1258979 | 0.72 | CHRM1 (0.51) | POLBSMN1; SMN2ALDH1A1KDM4ECHRM1 | |
| SCHEMBL14968784 | 0.72 | P2RX7 (0.43) | NPC1RAB9ACYP19A1P2RX7KDM4E | |
| SCHEMBL2176754 | 0.71 | P2RX7 (0.42) | NPC1RAB9ACYP19A1P2RX7KDM4E | |
| SCHEMBL2176759 | 0.71 | P2RX7 (0.42) | NPC1RAB9ACYP19A1P2RX7KDM4E | |
| SCHEMBL31288012 | 0.71 | PARP10 (0.33) | POLBNPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL640541 | 0.71 | CSNK1A1 (0.46) | MAPK1SMN1; SMN2ALDH1A1KDM4EALPL | |
| SCHEMBL7470027 | 0.71 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409489-A1 | 6-PHENYLDIHYDROPYRROLOPYRIMIDINEDIONE DERIVATIVES | Almirall Prodesfarma, S.A. (ES) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003000694-A1 | 6-PHENYLDIHYDROPYRROLOPYRIMIDINEDIONE DERIVATIVES | ALMIRALL PRODESFARMA S.A. (ES) | 2003-01-03 | — | — | WO | disclosed |