Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4557709 | 0.86 | ALDH1A1 (0.44) | P2RX7CYP19A1TDP1KDM4ECYP1A2 | |
| SCHEMBL2176759 | 0.82 | P2RX7 (0.42) | P2RX7HSP90AA1CYP19A1MKNK1HPGDS | |
| SCHEMBL2176754 | 0.82 | P2RX7 (0.42) | P2RX7HSP90AA1CYP19A1MKNK1HPGDS | |
| SCHEMBL28300910 | 0.75 | P2RX7 (0.40) | P2RX7HSP90AA1CYP19A1MKNK1ADORA3 | |
| SCHEMBL6683880 | 0.72 | POLB (0.38) | P2RX7CYP19A1TDP1KDM4ECYP3A4 | |
| SCHEMBL4263709 | 0.72 | — | — | |
| SCHEMBL11643934 | 0.71 | P2RX7 (0.38) | P2RX7HSP90AA1CYP19A1HPGDSGRM4 | |
| SCHEMBL16150460 | 0.71 | P2RX7 (0.42) | P2RX7HSP90AA1CYP19A1ADORA3KDM4E | |
| SCHEMBL4230876 | 0.70 | CYP17A1 (0.39) | P2RX7MKNK1SIRT3TSHRF7 | |
| SCHEMBL11879896 | 0.69 | HSP90AA1 (0.38) | P2RX7HSP90AA1CYP19A1HPGDSCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |