Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL765016 | 0.71 | POLB (0.43) | TDP1L3MBTL1POLBSMN1; SMN2HSD17B10 | |
| SCHEMBL6464252 | 0.70 | CFTR (0.44) | POLBSMN1; SMN2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4476398 | 0.69 | L3MBTL1 (0.50) | L3MBTL1POLBSMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL7415087 | 0.66 | MLYCD (0.64) | TDP1L3MBTL1POLBSMN1; SMN2HSD17B10 | |
| SCHEMBL4484792 | 0.66 | USP2 (0.41) | L3MBTL1SMN1; SMN2ALDH1A1HPGDTSHR | |
| SCHEMBL8317330 | 0.66 | MAPK1 (0.62) | TDP1POLBSMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL166344 | 0.66 | GAA (0.42) | TDP1L3MBTL1POLBSMN1; SMN2CYP3A4 | |
| SCHEMBL5913235 | 0.63 | EPHX2 (0.52) | SMN1; SMN2HPGDEPHX2NR1H4NPC1 | |
| SCHEMBL15013037 | 0.62 | SMN1; SMN2 (0.56) | POLBSMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL7850276 | 0.62 | RIPK1 (0.49) | POLBSMN1; SMN2CYP2C19ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487828-A2 | MORPHOLINYL-UREA DERIVATIVES FOR USE OF THE TREATMENT OF INFLAMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003082861-A2 | MORPHOLINYL-UREA DERIVATIVES FOR USE OF THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2003-10-09 | — | — | WO | disclosed |