Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6692009 | 0.92 | CA12 (0.46) | PARP1CNR2 | |
| SCHEMBL6697103 | 0.86 | PARP1 (0.43) | PARP1POLBCHKAHPGDKMT2A | |
| SCHEMBL6927393 | 0.81 | PARP1 (0.56) | PARP1POLBHPGDKMT2AALDH1A1 | |
| SCHEMBL6687780 | 0.81 | PARP1 (0.46) | PARP1POLBCHKAHPGDKMT2A | |
| SCHEMBL6692575 | 0.80 | LMNA (0.45) | PARP1CHKAHPGDKMT2AALDH1A1 | |
| SCHEMBL6692012 | 0.79 | CA2 (0.42) | PARP1 | |
| SCHEMBL6692232 | 0.78 | KMT2A (0.49) | POLBHPGDKMT2AALDH1A1MEN1 | |
| SCHEMBL6703688 | 0.74 | PARP1 (0.49) | PARP1POLBHPGDKMT2AMEN1 | |
| SCHEMBL6687434 | 0.74 | HPGD (0.44) | PARP1CHKAHPGDKMT2AALDH1A1 | |
| SCHEMBL23981505 | 0.73 | POLB (0.42) | PARP1POLBKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074438-A2 | CCR8 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | claimed |