Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23453341 | 0.86 | KMT2A (0.54) | HDAC3HDAC11HDAC8HDAC6DEGS1 | |
| SCHEMBL11356835 | 0.83 | HDAC8 (0.64) | HDAC3HDAC11HDAC8HDAC6DEGS1 | |
| SCHEMBL30797302 | 0.83 | CNR1 (0.44) | MITFEPHX2NPC1JAK3RAB9A | |
| SCHEMBL3824110 | 0.82 | MITF (0.63) | HDAC3HDAC11HDAC8HDAC6DEGS1 | |
| SCHEMBL30797103 | 0.81 | CNR1 (0.43) | MITFEPHX2ALDH1A1HPGDNPC1 | |
| SCHEMBL14113721 | 0.81 | NPC1 (0.61) | EPHX2ALDH1A1NPC1EPHX1JAK3 | |
| SCHEMBL23406287 | 0.81 | EPHX1 (0.71) | HDAC3HDAC11HDAC8HDAC6DEGS1 | |
| SCHEMBL20589978 | 0.81 | EPHX1 (0.71) | HDAC3HDAC11HDAC8HDAC6DEGS1 | |
| SCHEMBL23406306 | 0.81 | EPHX1 (0.67) | HDAC3HDAC11HDAC8HDAC6DEGS1 | |
| SCHEMBL20588941 | 0.80 | EPHX1 (0.69) | HDAC3HDAC11HDAC8HDAC6DEGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022177121-A1 | PROHIBITIN COMPANION DIAGNOSTIC COMPOSITION FOR LEUKEMIA TARGETED TREATMENT | 전남대학교산학협력단 | 2022-08-25 | — | — | WO | disclosed |
| US-20210163404-A1 | NOVEL UREA COMPOUNDS AND BIOISOSTERES THEREOF AND THEIR USE FOR TREATING INFLAMMATION AND INFLAMMATION-RELATED PATHOLOGIES | UNIVERSITé LAVAL (CA) | 2021-06-03 | — | — | US | disclosed |
| WO-2018227300-A1 | NOVEL UREA COMPOUNDS AND BIOISOSTERES THEREOF AND THEIR USE FOR TREATING INFLAMMATION AND INFLAMMATION-RELATED PATHOLOGIES | UNIVERSITé LAVAL (CA) | 2018-12-20 | — | — | WO | disclosed |
| WO-2004106291-A1 | HALOETHYL UREA COMPOUNDS AND THE USE THEREOF TO ATTENUATE, INHIBIT OR PREVENT CANCER CELL MIGRATION | IMOTEP INC. (CA) | 2004-12-09 | — | — | WO | disclosed |
| WO-2004106292-A1 | HALOETHYL UREA COMPOUNDS AND THEIR USE TO ATTENUATE, INHIBIT OR PREVENT NON-CANCEROUS PATHOGENIC CELLULAR PROLIFERATION AND DISEASES ASSOCIATED THEREWITH | IMOTEP INC. (CA) | 2004-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163404-A1 | NOVEL UREA COMPOUNDS AND BIOISOSTERES THEREOF AND THEIR USE FOR TREATING INFLAMMATION AND INFLAMMATION-RELATED PATHOLOGIES | NOS3, NOS2, CBS | HDAC3 2712/4885HDAC11 2707/4885HDAC8 3155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.