Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689841 | 0.83 | ALOX5 (0.34) | LMNASMN1; SMN2GAAMAPTRAB9A | |
| SCHEMBL6317151 | 0.79 | KMT2A (0.36) | LMNASMN1; SMN2GAAMAPTPKM | |
| SCHEMBL6316994 | 0.77 | LMNA (0.43) | LMNASMN1; SMN2GAAMAPTPKM | |
| SCHEMBL6315276 | 0.76 | LMNA (0.42) | LMNASMN1; SMN2GAAMAPTPKM | |
| SCHEMBL6407520 | 0.75 | RAB9A (0.36) | LMNASMN1; SMN2GAARAB9AKDM4E | |
| SCHEMBL6315846 | 0.75 | SMN1; SMN2 (0.40) | LMNASMN1; SMN2GAAMAPTPKM | |
| SCHEMBL6692830 | 0.75 | LMNA (0.35) | LMNASMN1; SMN2GAAMAPTRAB9A | |
| SCHEMBL6322114 | 0.74 | ALDH1A1 (0.35) | LMNASMN1; SMN2GAAMAPTRAB9A | |
| SCHEMBL6315749 | 0.73 | GAA (0.42) | LMNASMN1; SMN2GAAMAPTPKM | |
| SCHEMBL6316297 | 0.72 | MAPK14 (0.40) | LMNASMN1; SMN2GAAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377549-A1 | FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR | Millennium Pharmaceuticals, Inc. (US) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002072549-A1 | FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-09-19 | — | — | WO | disclosed |