Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689299 | 0.83 | LMNA (0.35) | LMNASMN1; SMN2GAARAB9AMAPT | |
| SCHEMBL6322135 | 0.81 | MDM2 (0.37) | ALOX5NPSR1MDM2LMNAMAPT | |
| SCHEMBL6316063 | 0.78 | HPGD (0.41) | ALOX5LMNASMN1; SMN2PTGS2MAPT | |
| SCHEMBL6407520 | 0.78 | RAB9A (0.36) | ALOX5MDM2NR1H2NR1H3LMNA | |
| SCHEMBL6317246 | 0.77 | ALDH1A1 (0.41) | ALOX5LMNASMN1; SMN2GAAMAPT | |
| SCHEMBL6323321 | 0.76 | AVPR1B (0.38) | ALOX5LMNASMN1; SMN2GAAOPRM1 | |
| SCHEMBL6692830 | 0.75 | LMNA (0.35) | LMNASMN1; SMN2GAARAB9AMAPT | |
| SCHEMBL6320591 | 0.75 | ALOX5 (0.39) | ALOX5LMNASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL6316709 | 0.71 | LMNA (0.42) | ALOX5MDM2LMNASMN1; SMN2GAA | |
| SCHEMBL6315618 | 0.69 | ALOX5 (0.39) | ALOX5MDM2LMNASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377549-A1 | FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR | Millennium Pharmaceuticals, Inc. (US) | 2004-01-07 | — | — | EP | claimed |
| WO-2002072549-A1 | FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-09-19 | — | — | WO | claimed |