SCHEMBL6690722

SCHEMBL6690722

COc1cc(Cl)c(-c2cc(OC(F)F)n(C)n2)cn1

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 3/20 0.34
KMT2A Q03164 1/20 0.32
TNF P01375 1/20 0.32
CRHR1 P34998 1/20 0.30
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6691871 0.86 KMT2A (0.32) F2RL3KMT2A
SCHEMBL6685844 0.80 PDE10A (0.30) KMT2A
SCHEMBL6671937 0.78 PDE2A (0.31) CRHR1
SCHEMBL6671534 0.77 F2RL3 (0.33) F2RL3TNFCRHR1
SCHEMBL6284972 0.76 HSD11B1 (0.42) F2RL3CRHR1
SCHEMBL7588842 0.76 L3MBTL1 (0.32) KMT2A
SCHEMBL6287494 0.75 SCN9A (0.33)
SCHEMBL6673150 0.75 KMT2A (0.39) KMT2A
SCHEMBL6818668 0.72 PDE4B (0.33) CRHR1
SCHEMBL6675401 0.72 NPC1 (0.35) KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004035564-A1 PYRIDINE DERIVATIVES USEFUL AS HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2004-04-29 WO disclosed
WO-2004035563-A1 3-HETEROCYCLYLPYRIDINE DERIVATIVES USEFUL AS HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2004-04-29 WO disclosed