Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 2/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.30 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL68795 | 0.76 | CCR1 (0.39) | — | |
| SCHEMBL144188 | 0.72 | METAP2 (0.52) | METAP2 | |
| SCHEMBL1617143 | 0.72 | METAP2 (0.57) | POLBMETAP2 | |
| SCHEMBL31215972 | 0.68 | POLB (0.45) | POLBESR1ESR2METAP2NQO2 | |
| SCHEMBL4075837 | 0.68 | POLB (0.41) | POLBESR1ESR2METAP2NQO2 | |
| SCHEMBL10476670 | 0.68 | BACE1 (0.47) | METAP2 | |
| SCHEMBL580188 | 0.67 | MMP2 (0.59) | POLBMETAP2 | |
| SCHEMBL14478402 | 0.65 | CCR1 (0.63) | POLBESR1ESR2NQO2HSD17B1 | |
| SCHEMBL23895465 | 0.64 | CCR1 (0.41) | POLBESR1ESR2NQO2 | |
| SCHEMBL16284364 | 0.64 | PARP1 (0.45) | POLBESR1ESR2METAP2NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012024558-A2 | LIGHT MEDIATED REGULATION OF PROTEIN DIMERIZATION | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-02-23 | — | — | WO | claimed |
| US-20110178281-A1 | Photocleavable Linker Methods and Compositions | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2011-07-21 | — | — | US | claimed |
| US-7923562-B2 | Photocleavable linker methods and compositions | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-04-12 | — | — | US | claimed |
| US-20100022761-A1 | PHOTOCLEAVABLE LINKER METHODS AND COMPOSITIONS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2010-01-28 | — | — | US | claimed |
| WO-2012024558-A2 | LIGHT MEDIATED REGULATION OF PROTEIN DIMERIZATION | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-02-23 | — | — | WO | disclosed |
| US-20110178281-A1 | Photocleavable Linker Methods and Compositions | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2011-07-21 | — | — | US | disclosed |
| US-7923562-B2 | Photocleavable linker methods and compositions | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-04-12 | — | — | US | disclosed |
| US-20100022761-A1 | PHOTOCLEAVABLE LINKER METHODS AND COMPOSITIONS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178281-A1 | Photocleavable Linker Methods and Compositions | NSUN2, RNGTT, METTL16 | POLB 388/4885ESR1 1832/4885ESR2 3046/4885 |
| US-20100022761-A1 | PHOTOCLEAVABLE LINKER METHODS AND COMPOSITIONS | NSUN2, RNGTT, METTL16 | POLB 388/4885ESR1 1832/4885ESR2 3046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.