SCHEMBL6691563

SCHEMBL6691563

CCOc1ccc2nc(SN(C3CCCCC3)C3CCCCC3)sc2c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.53
NPC1 O15118 4/20 0.53
MAPT P10636 9/20 0.52
KMT2A Q03164 5/20 0.52
SMN1; SMN2 Q16637 5/20 0.52
TP53 P04637 2/20 0.52
CYP3A4 P08684 2/20 0.52
MEN1 O00255 2/20 0.52
NFKB1 P19838 2/20 0.52
NFKB2 Q00653 2/20 0.52
RELA Q04206 2/20 0.52
CYP1A2 P05177 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
LMNA P02545 4/20 0.52
L3MBTL1 Q9Y468 3/20 0.52
MAPK1 P28482 1/20 0.52
HTT P42858 6/20 0.51
PPARA Q07869 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6697861 0.91 RAB9A (0.46) RAB9ANPC1MAPTKMT2ASMN1; SMN2
SCHEMBL6690252 0.91 RAB9A (0.44) RAB9ANPC1MAPTKMT2ASMN1; SMN2
SCHEMBL6690986 0.87 PDK1 (0.59) RAB9ANPC1MAPTKMT2ASMN1; SMN2
SCHEMBL6694305 0.82 CYP1A2 (0.41) RAB9ANPC1CYP1A2CYP2D6TSHR
SCHEMBL6694865 0.80 MAPT (0.61) RAB9ANPC1MAPTKMT2ASMN1; SMN2
SCHEMBL6690578 0.78 PPARA (0.48) RAB9ANPC1MAPTKMT2ASMN1; SMN2
SCHEMBL6689290 0.77 PDK1 (0.69) RAB9ANPC1MAPTKMT2ASMN1; SMN2
SCHEMBL6902202 0.77 MAPT (0.66) RAB9ANPC1MAPTKMT2ASMN1; SMN2
SCHEMBL6665955 0.76 MAPT (0.64) RAB9ANPC1MAPTKMT2ASMN1; SMN2
SCHEMBL6688611 0.75 ALDH1A1 (0.50) MAPTKMT2ASMN1; SMN2TP53MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869016-B1 Pneumatic radial tires BRIDGESTONE CORP (JP) 2004-03-03 EP disclosed
EP-0945482-B1 Rubber composition for tire tread and pneumatic tire using same BRIDGESTONE CORP (JP) 2004-01-28 EP disclosed
EP-1277795-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-22 EP disclosed
US-20020010283-A1 RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2002-01-24 US disclosed
US-6336486-B1 Pneumatic radical tire having cap base tread BRIDGESTONE CORPORATION (JP) 2002-01-08 US disclosed
US-6242522-B1 A DIENE BASED SYNTHETIC RUBBER OR NATURAL RUBBER BLEND CONTAINING BUTADIENE-STYRENE RUBBER, ALUMINUM HYDROXIDE POWDER, SILICA POWDER, CARBON BLACK; LOW FUEL CONSUMPTION AND WEAR RESISTANCE; IMPROVED GRIPPING IN WET AND COLD SITUATIONS BRIDGESTONE CORPORATION (JP) 2001-06-05 US disclosed
US-6186204-B1 EXCELLENT STABILITY AND CONTROLLABILITY ON WET ROADS OR A COMBINATION OF STABILITY AND CONTROLLABILITY ON WET ROADS AND EXCELLENT COMFORT OF RIDE EVEN WHEN A VEHICLE IS VIBRATING THROUGHOUT THE LIFE OF THE PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2001-02-13 US disclosed
EP-0948029-A2 High pressure discharge lamp NGK INSULATORS, LTD. (JP) 1999-10-06 EP disclosed
EP-0890605-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1999-01-13 EP disclosed
EP-0869016-A2 Pneumatic radial tires Bridgestone Corporation (JP) 1998-10-07 EP disclosed
EP-0854168-A1 Rubber composition Bridgestone Corporation (JP) 1998-07-22 EP disclosed