Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL11438714 | 0.96 | MEN1 (0.71) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Tromethamine SCHEMBL4365613 | 0.89 | MEN1 (0.71) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Tromethamine SCHEMBL1792376 | 0.89 | MEN1 (0.71) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Tromethamine SCHEMBL17484 | 0.88 | MEN1 (1.00) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL975 | 0.88 | — | — | |
| Tromethamine SCHEMBL3696191 | 0.88 | — | — | |
| Tromethamine SCHEMBL758262 | 0.85 | MEN1 (0.77) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Tromethamine SCHEMBL11444147 | 0.85 | MEN1 (0.77) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Tromethamine SCHEMBL9298764 | 0.84 | — | — | |
| Tromethamine SCHEMBL6427079 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649368-B1 | Enhancing antigenicity using solution of trisodium citrate, water, ethylene glycol monobutyl ether, nonylphenol ethoxylate, tetrapotassium pyrophosphate and surfactant; heating to remove paraffin; immunohistochemical staining | CELL MARQUE CORPORATION | 2003-11-18 | — | — | US | claimed |
| EP-3492562-A1 | FUEL COMPOSITIONS | Innospec Limited (GB) | 2019-06-05 | — | — | EP | disclosed |
| US-9157041-B2 | Fuel compositions | INNOSPEC LIMITED (GB) | 2015-10-13 | — | — | US | disclosed |
| US-20100299992-A1 | FUEL COMPOSITIONS | INNOSPEC LIMITED (GB) | 2010-12-02 | — | — | US | disclosed |
| EP-0669986-A1 | FULLY IMPAIRED CONSENSUS KOZAC SEQUENCES FOR MAMMALIAN EXPRESSION | IDEC PHARMACEUTICALS CORPORATION (US) | 1995-09-06 | — | — | EP | disclosed |
| WO-1994011523-A2 | FULLY IMPAIRED CONSENSUS KOZAC SEQUENCES FOR MAMMALIAN EXPRESSION | IDEC PHARMACEUTICALS CORPORATION (US) | 1994-05-26 | — | — | WO | disclosed |