SCHEMBL6692553

SCHEMBL6692553

NC(=O)OCCc1ccc(S(=O)(=O)c2ccc(O)c(C=O)c2)cc1

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 1/20 0.43
CA1 P00915 13/20 0.42
CA2 P00918 13/20 0.42
ALOX5 P09917 1/20 0.41
APP P05067 1/20 0.38
CA4 P22748 2/20 0.38
MET P08581 1/20 0.38
CA12 O43570 2/20 0.37
CA9 Q16790 2/20 0.37
YWHAG P61981 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6683308 0.80 CA1 (0.47) CA1CA2CA4METCA12
SCHEMBL6676148 0.79 AKR1B10 (0.45) CA1CA2ALOX5CA4MET
SCHEMBL6679212 0.77 LMNA (0.40) CA1CA2ALOX5
SCHEMBL6676179 0.77 LMNA (0.45) CA1CA2CA4CA12CA9
SCHEMBL13799682 0.77 ERN1 (0.56) CDK1
SCHEMBL27584202 0.75 CA2 (0.64) CA1CA2CA4CA12CA9
SCHEMBL28538352 0.71 F2 (0.56) CA1CA2CA4CA12CA9
SCHEMBL21693924 0.71 APP (0.68) ALOX5APPMETYWHAG
SCHEMBL1936121 0.71 LMNA (0.50) CA1CA2ALOX5APPCA4
SCHEMBL1316310 0.71 CDK1 (0.59) CDK1ALOX5APPMETYWHAG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004045610-A1 AMINOALCOHOL DERIVATIVES AND THEIR USE AS BETA-3 ADRENERGIC RECEPTOR AGONISTS FUJISAWA PHARMACEUTICAL CO., LTD (JP) 2004-06-03 WO disclosed