Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 4/20 | 0.40 |
| ▸ | FPR1 | P21462 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6693746 | 0.88 | PKM (0.41) | FPR2FPR1HDAC1HDAC8HDAC6 | |
| SCHEMBL6693015 | 0.88 | PKM (0.41) | FPR2FPR1HDAC1HDAC8HDAC6 | |
| SCHEMBL5158577 | 0.86 | FPR2 (0.46) | FPR2FPR1HDAC1HDAC8HDAC6 | |
| SCHEMBL5158579 | 0.86 | FPR2 (0.46) | FPR2FPR1HDAC1HDAC8HDAC6 | |
| SCHEMBL5160777 | 0.86 | FPR2 (0.46) | FPR2FPR1HDAC1HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL27460761 | 0.85 | FPR2 (0.45) | FPR2FPR1HDAC1HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL6431288 | 0.85 | FPR2 (0.44) | FPR2FPR1HDAC1HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL6431284 | 0.85 | FPR2 (0.44) | FPR2FPR1HDAC1HDAC8HDAC6 | |
| SCHEMBL1737713 | 0.81 | ROCK2 (0.41) | FPR2ROCK2MAPK1ALDH1A1MAPT | |
| SCHEMBL1737717 | 0.81 | ROCK2 (0.41) | FPR2ROCK2MAPK1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1113015-B1 | Optically active 3-((2-piperazinyl-phenyl)methyl)-1-(4-(trifluoromethyl)-phenyl)-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | PFIZER PROD INC (US) | 2004-09-15 | — | — | EP | disclosed |
| US-20030083337-A1 | Optically active 3-[(2-piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | PFIZER PRODUCTS, INC. | 2003-05-01 | — | — | US | disclosed |
| US-20010039280-A1 | Optically active 3-[(2-Piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT 1D receptor selective antagonists | PFIZER PRODUCTS INC. | 2001-11-08 | — | — | US | disclosed |
| EP-1113015-A1 | Optically active 3-((2-piperazinyl-phenyl)methyl)-1-(4-(trifluoromethyl)-phenyl)-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | Pfizer Products Inc. (US) | 2001-07-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010039280-A1 | Optically active 3-[(2-Piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT 1D receptor selective antagonists | HTR1D, HTR1A, HTR5A | FPR2 539/4885FPR1 253/4885HDAC1 1191/4885 |
| US-20030083337-A1 | Optically active 3-[(2-piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | HTR1D, HTR1A, HTR3D | FPR2 568/4885FPR1 224/4885HDAC1 1566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.