SCHEMBL6693377

SCHEMBL6693377

Fc1ccc(CNc2cccc(NCc3ccc(F)cc3F)c2)c(F)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 2/20 0.48
L3MBTL1 Q9Y468 4/20 0.48
MAPT P10636 3/20 0.48
CYP1A2 P05177 2/20 0.46
CYP2C9 P11712 2/20 0.46
CYP2C19 P33261 2/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
ATM Q13315 1/20 0.46
PLA2G1B P04054 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
ATG4B Q9Y4P1 1/20 0.46
PTGER2 P43116 1/20 0.46
MAOB P27338 2/20 0.46
KDM4E B2RXH2 1/20 0.46
LMNA P02545 2/20 0.46
NTRK1 P04629 1/20 0.45
HPGD P15428 2/20 0.45
ADRA2B P18089 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30339701 0.89 L3MBTL1 (0.52) PPARAL3MBTL1MAPTCYP1A2CYP2C9
SCHEMBL6693246 0.86 ADRA2B (0.53) L3MBTL1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL6691692 0.85 MAOB (0.47) PPARAL3MBTL1MAPTCYP1A2CYP2C9
SCHEMBL6691549 0.82 TP53 (0.48) L3MBTL1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL20219041 0.82 MAPT (0.48) L3MBTL1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL28750348 0.81 ADRA2B (0.45) PPARAL3MBTL1MAPTCYP1A2CYP2C9
SCHEMBL6701076 0.80 P2RX1 (0.48) L3MBTL1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL6690827 0.79 ALDH3A1 (0.42) PPARAMAPTMEN1KMT2APTGER2
SCHEMBL5544444 0.79 ADRA2B (0.46) L3MBTL1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL5180846 0.79 MEN1 (0.53) L3MBTL1MAPTCYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040009973-A1 Phenylenediamine derivatives N-substituted with benzyl- or heteroarylmethyl- groups 4SC AG (DE) 2004-01-15 US disclosed
WO-2003076388-A2 BIS-ANILINE DERIVATIVES USEFUL AS POTASSIUM CHANNELS MODULATORS 4SC AG (DE) 2003-09-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040009973-A1 Phenylenediamine derivatives N-substituted with benzyl- or heteroarylmethyl- groups PAH, PNMT, OPRM1 PPARA 2849/4885L3MBTL1 2590/4885MAPT 3951/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.