Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050275 | 0.87 | CHRM2 (0.40) | CHRM2IDO1CYP3A4GCKSMN1; SMN2 | |
| SCHEMBL6692739 | 0.84 | MEN1 (0.40) | IDO1SMN1; SMN2ALDH1A1MAPTHDAC6 | |
| SCHEMBL6694703 | 0.83 | P2RX7 (0.37) | CHRM2GCKSMN1; SMN2HTR1AALDH1A1 | |
| SCHEMBL6694698 | 0.79 | SMN1; SMN2 (0.36) | CHRM2GCKSMN1; SMN2HTR1AALDH1A1 | |
| SCHEMBL6700685 | 0.78 | MEN1 (0.41) | MAPTKDM4E | |
| SCHEMBL4050732 | 0.75 | RAB9A (0.38) | CASP1CASP3CASP7CASP8ALDH1A1 | |
| SCHEMBL6677177 | 0.71 | MMP12 (0.59) | — | |
| SCHEMBL4048796 | 0.71 | MEN1 (0.41) | SMN1; SMN2ALDH1A1MAPTHDAC6KDM4E | |
| SCHEMBL6692741 | 0.67 | HDAC6 (0.40) | SMN1; SMN2ALDH1A1MAPTHDAC6KDM4E | |
| SCHEMBL8739476 | 0.67 | EZH2 (0.63) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397137-A4 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL MYERS SQUIBB CO (US) | 2004-10-13 | — | — | EP | disclosed |
| EP-1397137-A1 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002096426-A1 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-12-05 | — | — | WO | disclosed |