Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050275 | 0.81 | CHRM2 (0.40) | SMN1; SMN2CHRM2GCKHTR1AALDH1A1 | |
| SCHEMBL6694701 | 0.79 | CHRM2 (0.39) | SMN1; SMN2CHRM2GCKHTR1AALDH1A1 | |
| SCHEMBL6694703 | 0.79 | P2RX7 (0.37) | SMN1; SMN2CHRM2GCKHTR1AALDH1A1 | |
| SCHEMBL6700679 | 0.78 | MMP12 (0.42) | MMP13MMP12MEN1KMT2A | |
| SCHEMBL8739476 | 0.69 | EZH2 (0.63) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4050732 | 0.68 | RAB9A (0.38) | ALDH1A1MAPTGAAKMT2A | |
| SCHEMBL6681647 | 0.66 | MMP2 (0.50) | MMP12 | |
| SCHEMBL4060462 | 0.65 | RXRA (0.55) | SMN1; SMN2ALDH1A1MAPTHDAC6KDM4E | |
| SCHEMBL6692739 | 0.63 | MEN1 (0.40) | SMN1; SMN2ALDH1A1MAPTHDAC6KDM4E | |
| SCHEMBL8738177 | 0.63 | EZH2 (0.67) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397137-A4 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL MYERS SQUIBB CO (US) | 2004-10-13 | — | — | EP | disclosed |
| EP-1397137-A1 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002096426-A1 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-12-05 | — | — | WO | disclosed |