Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6697320 | 0.77 | MAPT (0.40) | MAPTATMCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6694814 | 0.76 | CYP1A2 (0.38) | MAPTATMCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6694812 | 0.74 | MAPT (0.36) | MAPTATMCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL21076665 | 0.72 | MAPT (0.38) | MAPTALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL8151828 | 0.71 | MAPT (0.34) | MAPTATMALDH1A1KDM4ERAB9A | |
| SCHEMBL6697673 | 0.70 | MAPT (0.47) | MAPTATMCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6701919 | 0.70 | MAPT (0.43) | MAPTATMCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6696475 | 0.69 | CRHR1 (0.39) | MAPTATMCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6697459 | 0.69 | KMT2A (0.39) | MAPTATMCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6694037 | 0.69 | NPC1 (0.49) | MAPTATMCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759350-B2 | Pyrimidine carboxamides | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2010-07-20 | — | — | US | disclosed |
| US-7759350-B2 | Pyrimidine carboxamides | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2010-07-20 | — | — | US | disclosed |
| US-20070072876-A1 | Novel pyrimidine carboxamides | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2007-03-29 | — | — | US | disclosed |
| US-20070072876-A1 | Novel pyrimidine carboxamides | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2007-03-29 | — | — | US | disclosed |
| WO-2007031829-A2 | NOVEL PYRIMIDINE CARBOXAMIDES | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-03-22 | — | — | WO | disclosed |
| US-6835726-B2 | Pyrimidine derivatives | AMGEN INC. | 2004-12-28 | — | — | US | disclosed |
| US-20040006068-A1 | Pyrimidine derivatives | TULARIK INC. | 2004-01-08 | — | — | US | disclosed |
| US-20030130264-A1 | Methods of using pyrimidine-based antiviral agents | TULARIK INC. (US) | 2003-07-10 | — | — | US | disclosed |
| US-6528513-B2 | Viricides; especially cytomegalo virus | TULARIK INC | 2003-03-04 | — | — | US | disclosed |
| US-20010018436-A1 | Pyrimidine derivatives | TULARIK INC. | 2001-08-30 | — | — | US | disclosed |
| US-6200977-B1 | USEFUL IN TREATING AND SUPPRESSING HUMAN CYTOMEGALOVIRUS | TULARIK INC. | 2001-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072876-A1 | Novel pyrimidine carboxamides | UACA, SI, MYLK2 | MAPT 160/4885ATM 1306/4885CYP1A2 1567/4885 |
| US-20030130264-A1 | Methods of using pyrimidine-based antiviral agents | TYMP, TYMS, NUDT1 | MAPT 2656/4885ATM 3318/4885CYP1A2 3150/4885 |
| US-20010018436-A1 | Pyrimidine derivatives | TYMP, TYMS, UMPS | MAPT 1762/4885ATM 2349/4885CYP1A2 2657/4885 |
| US-20040006068-A1 | Pyrimidine derivatives | TYMP, TYMS, UMPS | MAPT 1762/4885ATM 2349/4885CYP1A2 2657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.