Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2870934 | 0.86 | PSIP1 (0.54) | PSIP1HSD11B1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL402822 | 0.79 | PSIP1 (0.56) | PSIP1HSD11B1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL6803055 | 0.76 | HSD11B1 (0.50) | PSIP1HSD11B1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL680611 | 0.76 | PSIP1 (0.70) | PSIP1HSD11B1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL15803386 | 0.75 | PSIP1 (0.43) | PSIP1HSD11B1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL28357379 | 0.75 | MMP13 (0.62) | ALDH1A1MEN1KMT2APOLBMMP3 | |
| SCHEMBL777601 | 0.75 | PSIP1 (0.67) | PSIP1HSD11B1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL19514690 | 0.75 | PSIP1 (0.50) | PSIP1HSD11B1MAPTALDH1A1L3MBTL1 | |
| Ammonia Solution, Strong SCHEMBL8909378 | 0.74 | PSIP1 (0.67) | PSIP1HSD11B1MAPTALDH1A1L3MBTL1 | |
| Fluoride SCHEMBL27365732 | 0.74 | PSIP1 (0.67) | PSIP1HSD11B1MAPTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040162314-A1 | Substituted 8-arylquinolune pde4 inhibitors | MERCK FROSST CANADA LTD. (CA) | 2004-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040162314-A1 | Substituted 8-arylquinolune pde4 inhibitors | PDE12, PDE4A, PDE4B | PSIP1 656/4885HSD11B1 1431/4885MAPT 3571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.