Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA1A | P0DMV8 | 4/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 4/20 | 0.47 |
| ▸ | EDNRA | P25101 | 5/20 | 0.43 |
| ▸ | EDNRB | P24530 | 4/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | GRK6 | P43250 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | GAPDH | P04406 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6216903 | 0.84 | EDNRA (0.47) | HSPA1APTPN7EDNRAEDNRBMCL1 | |
| SCHEMBL6640242 | 0.73 | ALDH1A1 (0.51) | HSPA1APTPN7EDNRAEDNRBALDH1A1 | |
| SCHEMBL6217804 | 0.72 | HSPA1A (0.43) | HSPA1APTPN7EDNRAEDNRBMCL1 | |
| SCHEMBL27911000 | 0.68 | PTPN7 (0.60) | HSPA1APTPN7EDNRAEDNRBMCL1 | |
| SCHEMBL23297838 | 0.63 | ALDH1A1 (0.51) | EDNRAEDNRBALDH1A1POLBMAPT | |
| SCHEMBL23342993 | 0.63 | ALDH1A1 (0.51) | EDNRAEDNRBALDH1A1POLBMAPT | |
| SCHEMBL29542982 | 0.63 | ALDH1A1 (0.51) | EDNRAEDNRBALDH1A1POLBMAPT | |
| SCHEMBL23297818 | 0.63 | ALDH1A1 (0.51) | EDNRAEDNRBALDH1A1POLBMAPT | |
| SCHEMBL29542709 | 0.63 | ALDH1A1 (0.51) | EDNRAEDNRBALDH1A1POLBMAPT | |
| Acetic Acid SCHEMBL30426275 | 0.62 | CA1 (0.56) | MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224969-A1 | Salts of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds | GRUENENTHAL GMBH (DE) | 2004-11-11 | — | — | US | disclosed |
| US-6699877-B2 | TREATING PAIN, MIGRAINE, AND VARIOUS OTHER DISEASES | GRUENENTHAL GMBH (DE) | 2004-03-02 | — | — | US | disclosed |
| US-20030087926-A1 | Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives | GRUENENTHAL GMBH | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087926-A1 | Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives | SDHA, CACNA1A, GRIN2C | HSPA1A 3371/4885PTPN7 3463/4885EDNRA 1506/4885 |
| US-20040224969-A1 | Salts of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds | OPRK1, SDHA, GRIN2C | HSPA1A 2266/4885PTPN7 4107/4885EDNRA 1417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.