Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 3/20 | 0.41 |
| ▸ | EDNRB | P24530 | 2/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6217806 | 0.85 | SNCA (0.37) | HSPA1APTPN7EDNRAEDNRBSNCA | |
| SCHEMBL6697316 | 0.72 | HSPA1A (0.47) | HSPA1APTPN7EDNRAEDNRBKDM1A | |
| SCHEMBL6216903 | 0.70 | EDNRA (0.47) | HSPA1APTPN7EDNRAEDNRBALDH1A1 | |
| SCHEMBL6769378 | 0.70 | EDNRA (0.41) | HSPA1APTPN7EDNRAEDNRBKDM1A | |
| SCHEMBL27911000 | 0.66 | PTPN7 (0.60) | HSPA1APTPN7EDNRAEDNRBALDH1A1 | |
| SCHEMBL14489506 | 0.65 | KDM1A (0.43) | SNCAKDM1AALDH1A1CASP1SMN1; SMN2 | |
| SCHEMBL12686733 | 0.62 | EDNRA (0.62) | EDNRAEDNRBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL12488726 | 0.62 | EDNRA (0.62) | EDNRAEDNRBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL23342993 | 0.61 | ALDH1A1 (0.51) | EDNRAEDNRBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL23297818 | 0.61 | ALDH1A1 (0.51) | EDNRAEDNRBALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411947-A2 | SALTS OF SUBSTITUTED 1, 2, 3, 4-TETRAHYDROISOQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2004-04-28 | — | — | EP | claimed |
| JP-2003522758-A | — | — | 2003-07-29 | — | — | JP | claimed |
| WO-2003013530-A2 | SALTS OF SUBSTITUTED 1, 2, 3, 4-TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES AS NMDA ANTAGONISTS | Grünenthal GmbH (DE) | 2003-02-20 | — | — | WO | claimed |
| EP-1254118-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2002-11-06 | — | — | EP | claimed |
| WO-2001058875-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2001-08-16 | — | — | WO | claimed |
| EP-1254118-B1 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | GRUENENTHAL GMBH (DE) | 2005-11-09 | — | — | EP | disclosed |
| US-20040224969-A1 | Salts of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds | GRUENENTHAL GMBH (DE) | 2004-11-11 | — | — | US | disclosed |
| EP-1411947-A2 | SALTS OF SUBSTITUTED 1, 2, 3, 4-TETRAHYDROISOQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2004-04-28 | — | — | EP | disclosed |
| US-6699877-B2 | TREATING PAIN, MIGRAINE, AND VARIOUS OTHER DISEASES | GRUENENTHAL GMBH (DE) | 2004-03-02 | — | — | US | disclosed |
| US-20030087926-A1 | Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives | GRUENENTHAL GMBH | 2003-05-08 | — | — | US | disclosed |
| WO-2003013530-A2 | SALTS OF SUBSTITUTED 1, 2, 3, 4-TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES AS NMDA ANTAGONISTS | Grünenthal GmbH (DE) | 2003-02-20 | — | — | WO | disclosed |
| EP-1254118-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001058875-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2001-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087926-A1 | Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives | SDHA, CACNA1A, GRIN2C | HSPA1A 3371/4885PTPN7 3463/4885EDNRA 1506/4885 |
| US-20040224969-A1 | Salts of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds | OPRK1, SDHA, GRIN2C | HSPA1A 2266/4885PTPN7 4107/4885EDNRA 1417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.