Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.49 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.49 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | FABP3 | P05413 | 1/20 | 0.45 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NCS1 | P62166 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6501691 | 0.87 | FABP3 (0.52) | ITGB1ITGA4ADAMTS7MAPTTP53 | |
| SCHEMBL13495445 | 0.87 | MAPT (0.55) | ITGB1ITGA4MAPTFABP3FABP4 | |
| SCHEMBL14585873 | 0.86 | ITGB1 (0.47) | ITGB1ITGA4ADAMTS7MAPTTP53 | |
| SCHEMBL4203346 | 0.84 | MTTP (0.52) | CFTRPDK2 | |
| SCHEMBL6705895 | 0.84 | CFTR (0.48) | ADAMTS7MAPTCFTRSLC6A4SLC6A3 | |
| SCHEMBL6704698 | 0.83 | MRGPRX4 (0.49) | ADAMTS7CFTRSLC6A4SLC6A3PDK2 | |
| SCHEMBL7174236 | 0.82 | FABP4 (0.62) | MAPTTP53CFTRFABP3FABP4 | |
| SCHEMBL1133231 | 0.82 | AR (0.53) | ITGB1ITGA4PDK2KDM4EHPGD | |
| SCHEMBL6704771 | 0.81 | CFTR (0.45) | CFTRSLC6A4SLC6A3PDK2MRGPRX4 | |
| SCHEMBL18315876 | 0.80 | TSHR (0.56) | MAPTCFTRFABP3FABP4FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9656960-B2 | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion | SURFACE LOGIX, INC. (US) | 2017-05-23 | — | — | US | disclosed |
| US-9656960-B2 | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion | SURFACE LOGIX, INC. (US) | 2017-05-23 | — | — | US | disclosed |
| US-20160039765-A1 | INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND APO-B SECRETION | KADMON CORPORATION, LLC | 2016-02-11 | — | — | US | disclosed |
| US-20160039765-A1 | INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND APO-B SECRETION | KADMON CORPORATION, LLC | 2016-02-11 | — | — | US | disclosed |
| US-8980915-B2 | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion | SURFACE LOGIX, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-8980915-B2 | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion | SURFACE LOGIX, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| EP-1877369-B1 | INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND APO-B SECRETION | SURFACE LOGIX INC (US) | 2013-07-10 | — | — | EP | disclosed |
| US-20070027183-A1 | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion | SURFACE LOGIX, INC. (US) | 2007-02-01 | — | — | US | disclosed |
| US-20070027183-A1 | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion | SURFACE LOGIX, INC. (US) | 2007-02-01 | — | — | US | disclosed |
| US-20040044008-A1 | Use of therapeutic benzamide derivatives | DAUGAN ALAIN CLAUDE-MARIE (FR) | 2004-03-04 | — | — | US | disclosed |
| US-6552022-B1 | Atherosclerosis in a mammal, pancreatitis, non-insulin dependent diabetes mellitus, coronary heart disease in a lowering serum lipid levels | SMITHKLINE BEECHAM CORPORATION | 2003-04-22 | — | — | US | disclosed |
| EP-1286670-A2 | USE OF THERAPEUTIC BENZAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001097810-A2 | USE OF THERAPEUTIC BENZAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-12-27 | — | — | WO | disclosed |
| EP-1135378-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS APOB-100 SECRETION INHIBITORS | GLAXO GROUP LIMITED (GB) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000032582-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS APOB-100 SECRETION INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039765-A1 | INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND APO-B SECRETION | APOB, CETP, MTTP | ITGB1 4284/4885ITGA4 4661/4885ADAMTS7 2093/4885 |
| US-20070027183-A1 | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion | APOB, CETP, MTTP | ITGB1 4284/4885ITGA4 4661/4885ADAMTS7 2093/4885 |
| US-20040044008-A1 | Use of therapeutic benzamide derivatives | MTTP, LIPC, CETP | ITGB1 4285/4885ITGA4 4308/4885ADAMTS7 3283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.