Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.69 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.69 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.69 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | KDM5C | P41229 | 3/20 | 0.45 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.45 |
| ▸ | KDM6B | O15054 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.45 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL5498204 | 0.90 | LMNA (0.58) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL1539751 | 0.87 | LMNA (0.55) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL15323174 | 0.87 | LMNA (0.53) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Formic Acid SCHEMBL30781645 | 0.87 | LMNA (0.53) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Glutarate SCHEMBL27542711 | 0.86 | SLC22A6 (0.73) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Adipic Acid SCHEMBL28091043 | 0.86 | LMNA (0.73) | LMNASLC22A6OR51E2TSHRNFKB1 | |
| Alpha-Ketoglutaric Acid SCHEMBL15391860 | 0.85 | EGLN1 (0.78) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Levulinic Acid SCHEMBL16114767 | 0.85 | LMNA (0.78) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL4269130 | 0.83 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL24696 | 0.83 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105324347-B | Purposes of the octyl group ester polymer of acrylic acid 2 as the adhesive in coating composition | 阿肯马法国公司 | 2018-03-30 | — | — | CN | claimed |
| EP-0157043-A2 | The production of mannitol and higher mannosaccharide alcohols | GENERAL FOODS CORPORATION (US) | 1985-10-09 | — | — | EP | claimed |
| US-4484012-A | HYDROLYSIS OF SPENT COFFEE GROUNDS AND REDUCTION OF THE RESULTING MANNG-SACCHARIDES | GENERAL FOODS CORPORATION (US) | 1984-11-20 | — | — | US | claimed |
| CN-108137471-A | Detach carboxylic acid | 罗门哈斯公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-107848851-A | Dirt suppresses polymer composition, mixture and its application method | 艺康美国股份有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-107848972-A | For preparing N (4 luorobenzyl) N (base of 1 methyl piperidine 4) N ' (4 (2 methyl propoxyl group) phenyl methyl) ureas and its tartrate and polymorphic C method | 阿卡蒂亚药品公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-107406664-A | Thermoplastic resin composition, lid material and easily openable container | 安姆希比创新咨询有限公司 | 2017-11-28 | — | — | CN | disclosed |
| CN-104919365-B | Liquid crystal sealing agent and use its liquid crystal display | 日本化药株式会社 | 2017-11-21 | — | — | CN | disclosed |
| CN-106715009-A | Metallic copper particles, and production method therefor | 石原产业株式会社 | 2017-05-24 | — | — | CN | disclosed |
| CN-104955466-A | Synergistic bacterial compositions and methods of production and use thereof | SERES HEALTH INC | 2015-09-30 | — | — | CN | disclosed |
| US-20040235792-A1 | Serine protease inhibitors compromising a hydrogen-bond acceptor | TRIGEN LIMITED (GB) | 2004-11-25 | — | — | US | disclosed |
| WO-2002057273-A9 | SERINE PROTEASE INHIBITORS COMPRISING A HYDROGEN-BOND ACCEPTOR | TRIGEN LTD (GB) | 2002-11-28 | — | — | WO | disclosed |
| WO-2002057273-A1 | SERINE PROTEASE INHIBITORS COMPRISING A HYDROGEN-BOND ACCEPTOR | TRIGEN LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |
| EP-0418486-B1 | Reagent useful for detection and quantitative determination of leukocytes in biological fluids and method of using it | DIESSE DIAGNOSTICA (IT) | 1994-11-02 | — | — | EP | disclosed |
| US-5128265-A | REAGENT USEFUL FOR DETECTION AND QUANTITATIVE DETERMINATION OF LEUKOCYTES IN BIOLOGICAL FLUIDS | DIESSE DIAGNOSTICA SENESE S.R.L. (IT) | 1992-07-07 | — | — | US | disclosed |
| EP-0418486-A2 | Reagent useful for detection and quantitative determination of leukocytes in biological fluids and method of using it | DIESSE DIAGNOSTICA SENESE s.r.l. (IT) | 1991-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235792-A1 | Serine protease inhibitors compromising a hydrogen-bond acceptor | SERPINB1, SPINT2, CTRL | LMNA 1148/4885EGLN1 1098/4885ALKBH5 3743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.