Sugi Predict

Sugi Predict / Compounds / SCHEMBL670276

SCHEMBL670276

SCHEMBL670276

COCCOc1cccc(I)c1

nearest known ligand 0.48

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 3/20 0.46
▸ CYP1A2 P05177 1/20 0.46
▸ CYP2D6 P10635 1/20 0.46
▸ CYP2C19 P33261 1/20 0.46
▸ APP P05067 1/20 0.45
▸ KDM4E B2RXH2 2/20 0.42
▸ ALDH1A1 P00352 2/20 0.42
▸ SYK P43405 1/20 0.42
▸ KMT2A Q03164 1/20 0.41
▸ NPSR1 Q6W5P4 1/20 0.41
▸ L3MBTL1 Q9Y468 2/20 0.40
▸ PRSS1 P07477 2/20 0.40
▸ LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29584039 1.00 MAPK1 (0.46) MAPK1CYP1A2CYP2D6CYP2C19APP
SCHEMBL8969657 0.95 TSHR (0.46) MAPK1CYP1A2CYP2D6CYP2C19APP
SCHEMBL13846053 0.91 CYP1A2 (0.53) MAPK1CYP1A2CYP2D6CYP2C19APP
SCHEMBL10048853 0.91 CYP1A2 (0.53) MAPK1CYP1A2CYP2D6CYP2C19APP
SCHEMBL13845920 0.89 CYP1A2 (0.51) MAPK1CYP1A2CYP2D6CYP2C19KDM4E
SCHEMBL6089644 0.86 APP (0.41) MAPK1CYP1A2CYP2D6CYP2C19APP
SCHEMBL15723552 0.86 MAPK1 (0.58) MAPK1CYP1A2CYP2D6CYP2C19KDM4E
SCHEMBL8552100 0.82 KMT2A (0.59) MAPK1KDM4EALDH1A1KMT2ALMNA
SCHEMBL3657469 0.82 APP (0.46) MAPK1CYP1A2CYP2D6CYP2C19APP
SCHEMBL30500239 0.82 APP (0.46) MAPK1CYP1A2CYP2D6CYP2C19APP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111170991-B Antiproliferative compounds and methods of synthesis thereof 细胞基因公司 2023-10-31 — — CN disclosed
EP-3594211-B1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORP (US) 2023-10-25 — — EP disclosed
US-20230203002-A1 6-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME TREVENA, INC. 2023-06-29 — — US disclosed
US-20230203002-A1 6-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME TREVENA, INC. 2023-06-29 — — US disclosed
US-20230203002-A1 6-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME TREVENA, INC. 2023-06-29 — — US disclosed
CN-114813603-B Method for rapidly characterizing halogenation reaction conversion rate of phenolic hydroxyl compound without standard substance 南京林业大学 2023-06-20 — — CN disclosed
US-20220387413-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORP (US) 2022-12-08 — — US disclosed
EP-4086249-A2 6-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME Trevena, Inc. (US) 2022-11-09 — — EP disclosed
EP-4086249-A2 6-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME Trevena, Inc. (US) 2022-11-09 — — EP disclosed
US-11465980-B2 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same TREVENA, INC. (US) 2022-10-11 — — US disclosed
EP-2885284-A1 PYRAZOLYL-UREAS AS KINASE INHIBITORS Respivert Limited (GB) 2015-06-24 — — EP disclosed
US-8895552-B2 Cyclic amide derivative SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2014-11-25 — — US disclosed
US-20140057915-A1 KINASE INHIBITORS TOPIVERT PHARMA LIMITED (GB) 2014-02-27 — — US disclosed
US-20140057915-A1 KINASE INHIBITORS TOPIVERT PHARMA LIMITED (GB) 2014-02-27 — — US disclosed
US-20140057915-A1 KINASE INHIBITORS TOPIVERT PHARMA LIMITED (GB) 2014-02-27 — — US disclosed
WO-2014027209-A1 PYRAZOLYL-UREAS AS KINASE INHIBITORS RESPIVERT LIMITED (GB) 2014-02-20 — — WO disclosed
US-20130217692-A1 CYCLIC AMIDE DERIVATIVE DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2013-08-22 — — US disclosed
WO-2012047764-A1 THERAPEUTIC ANTIVIRAL PEPTIDES INTERMUNE, INC. (US) 2012-04-12 — — WO disclosed
WO-2012024584-A2 OXYSTEROL COMPOUNDS FATE THERAPEUTICS, INC. (US) 2012-02-23 — — WO disclosed
WO-2008089005-A2 RENIN INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-07-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220387413-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF MCL1, MKI67, BAX MAPK1 1825/4885CYP1A2 2288/4885CYP2D6 1559/4885
US-11465980-B2 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same OPRD1, OPRM1, OPRK1 MAPK1 3855/4885CYP1A2 686/4885CYP2D6 263/4885
US-20140057915-A1 KINASE INHIBITORS SYK, BTK, LYN MAPK1 11/4885CYP1A2 2533/4885CYP2D6 2957/4885
US-20130217692-A1 CYCLIC AMIDE DERIVATIVE HDAC10, H1-10, H1-0 MAPK1 918/4885CYP1A2 75/4885CYP2D6 269/4885
US-20230203002-A1 6-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME OPRD1, OPRM1, OPRK1 MAPK1 3855/4885CYP1A2 686/4885CYP2D6 263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.