SCHEMBL6705063

SCHEMBL6705063

Clc1cccc(Cl)c1[CH]c1c(Cl)cccc1Cl

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.60
KMT2A Q03164 2/20 0.60
MEN1 O00255 1/20 0.60
TDP1 Q9NUW8 1/20 0.60
CYP2A6 P11509 3/20 0.47
CYP1A2 P05177 2/20 0.47
TSHR P16473 3/20 0.47
LMNA P02545 1/20 0.47
HSP90AA1 P07900 1/20 0.44
SLC22A1 O15245 1/20 0.43
HTR1A P08908 1/20 0.43
ADRA2A P08913 1/20 0.43
CHRM1 P11229 1/20 0.43
ADRA2B P18089 1/20 0.43
ADRA2C P18825 1/20 0.43
MAOA P21397 1/20 0.43
DRD1 P21728 1/20 0.43
TBXA2R P21731 1/20 0.43
SLC6A2 P23975 1/20 0.43
ADRA1D P25100 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5247979 0.81 ALDH1A1 (0.48) ALDH1A1KMT2AMEN1TDP1CYP2A6
SCHEMBL8579781 0.78 ALDH1A1 (0.57) ALDH1A1KMT2AMEN1TDP1CYP2A6
SCHEMBL11684123 0.75 ALDH1A1 (0.55) ALDH1A1KMT2AMEN1TDP1CYP2A6
SCHEMBL96214 0.75 ALDH1A1 (1.00) ALDH1A1KMT2AMEN1TDP1CYP2A6
SCHEMBL181965 0.75 ALDH1A1 (0.55) ALDH1A1KMT2AMEN1TDP1CYP2A6
SCHEMBL1547930 0.75 ALDH1A1 (0.55) ALDH1A1KMT2AMEN1TDP1CYP2A6
SCHEMBL5781095 0.75 ALDH1A1 (0.55) ALDH1A1KMT2AMEN1TDP1CYP2A6
SCHEMBL4871529 0.75 ALDH1A1 (0.55) ALDH1A1KMT2AMEN1TDP1CYP2A6
SCHEMBL131082 0.75 ALDH1A1 (0.55) ALDH1A1KMT2AMEN1TDP1CYP2A6
SCHEMBL2096364 0.74 TDP1 (0.52) ALDH1A1KMT2AMEN1TDP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4400520-A1 CATALYST FOR OLEFIN POLYMERIZATION AND METHOD FOR PRODUCING OLEFIN POLYMER The University of Tokyo (JP) 2024-07-17 EP disclosed
CN-118176220-A Catalyst for olefin polymerization and process for producing olefin polymer 国立大学法人东京大学 2024-06-11 CN disclosed
WO-2023037849-A1 CATALYST FOR OLEFIN POLYMERIZATION AND METHOD FOR PRODUCING OLEFIN POLYMER 国立大学法人 東京大学 2023-03-16 WO disclosed
US-20040248963-A1 Prodrugs of excitatory amino acids ELI LILLY AND COMPANY 2004-12-09 US disclosed
EP-1463713-A1 PRODRUGS OF EXCITATORY AMINO ACIDS ELI LILLY AND COMPANY (US) 2004-10-06 EP disclosed
US-6620940-B1 Heterocyclic nitrogen/sulfur compounds used as chemical intermediates for drugs such as 3-chloro-4-(furan-2-yl)-1,2,5 -thiadiazole ELI LILLY AND COMPANY 2003-09-16 US disclosed
WO-2003045898-A1 PRODRUGS OF EXCITATORY AMINO ACIDS ELI LILLY AND COMPANY (US) 2003-06-05 WO disclosed
US-6372945-B1 OXIDIZING BENZYL SULFIDE, REACTING BENZYL SULFOXIDE FORMED WITH STRONG BASE TO FORM BENZYLIC ANION, CONDENSING ANION WITH BENZALDEHYDE, REACTING CONDENSATION PRODUCT WITH ACID CHLORIDE TO PRODUCE ESTER, TREATING ESTER WITH STRONG BASE ELI LILLY AND COMPANY 2002-04-16 US disclosed
EP-0830356-B1 PROCESS FOR THE SYNTHESIS OF BENZO(b)THIOPHENES LILLY CO ELI (US) 2001-08-22 EP disclosed
EP-1092714-A2 Process for the synthesis of benzo[b]thiophenes Eli Lilly & Company (US) 2001-04-18 EP disclosed
US-5606075-A CYCLIZATION IN THE PRESENCE OF AN ACID CATALYST ELI LILLY AND COMPANY (US) 1997-02-25 US disclosed
US-5606076-A CYCLIZATION IN PRESENCE OF AN ACID CATALYST ELI LILLY AND COMPANY (US) 1997-02-25 US disclosed
WO-1996040677-A1 PROCESS FOR THE SYNTHESIS OF BENZO[b]THIOPHENES ELI LILLY AND COMPANY (US) 1996-12-19 WO disclosed
WO-1996040693-A1 PROCESS FOR THE SYNTHESIS OF VINYL SULFENIC ACID DERIVATIVES ELI LILLY AND COMPANY (US) 1996-12-19 WO disclosed
WO-1996040676-A1 PROCESS FOR THE SYNTHESIS OF BENZO[b]THIOPHENES ELI LILLY AND COMPANY (US) 1996-12-19 WO disclosed
US-5569772-A CHEMICAL INTERMEDIATES ELI LILLY AND COMPANY (US) 1996-10-29 US disclosed
US-5514826-A INTERMEDIATES FOR 2-ARYLBENZO(B)THIOPHENES ELI LILLY AND COMPANY (US) 1996-05-07 US disclosed
US-5512701-A REACTING SULFOXIDE DERIVATIVE WITH A SILYATING AGENT TO FORM SULFENATE SILYL ESTER, OPTIONALLY REACTING INTERMEDIATE WITH AN AMINE AND/OR A MERCAPTAN ELI LILLY AND COMPANY (US) 1996-04-30 US disclosed
WO-1996005175-A1 SYNTHETIC EXCITATORY AMINO ACIDS ELI LILLY AND COMPANY (US) 1996-02-22 WO disclosed
EP-0696577-A1 Synthetic excitatory amino acids ELI LILLY AND COMPANY (US) 1996-02-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040248963-A1 Prodrugs of excitatory amino acids SLC1A2, SLC1A1, SLC1A3 ALDH1A1 539/4885KMT2A 865/4885MEN1 1396/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.