Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19871757 | 0.83 | TSHR (0.48) | ALDH1A1KMT2AMEN1TDP1CYP1A2 | |
| SCHEMBL8186922 | 0.83 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1TDP1CYP1A2 | |
| SCHEMBL19880549 | 0.78 | KMT2A (0.45) | ALDH1A1KMT2AMEN1TDP1HSP90AA1 | |
| SCHEMBL19779677 | 0.78 | CYP1A2 (0.42) | ALDH1A1KMT2AMEN1TDP1CYP1A2 | |
| SCHEMBL6705063 | 0.75 | ALDH1A1 (0.60) | ALDH1A1KMT2AMEN1TDP1CYP1A2 | |
| SCHEMBL172044 | 0.74 | CYP3A4 (0.36) | ALDH1A1KMT2AMEN1TDP1CYP2A6 | |
| SCHEMBL8579781 | 0.73 | ALDH1A1 (0.57) | ALDH1A1KMT2AMEN1TDP1CYP1A2 | |
| SCHEMBL28646735 | 0.71 | SLC22A1 (0.50) | ALDH1A1KMT2AMEN1TDP1CYP1A2 | |
| SCHEMBL5781095 | 0.71 | ALDH1A1 (0.55) | ALDH1A1KMT2AMEN1TDP1CYP1A2 | |
| SCHEMBL21600440 | 0.71 | ALDH1A1 (0.45) | ALDH1A1KMT2AMEN1TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551396-A1 | PIN1-MODULATING COMPOUNDS AND METHODS OF USE THEREOF | Pintex Pharmaceuticals, Inc. (US) | 2005-07-13 | — | — | EP | claimed |
| WO-2004093803-A2 | PHOTOCHEMOTHERAPEUTIC COMPOUNDS FOR USE IN TREATMENT OF PIN1-ASSOCIATED STATES | PINTEX PHARMACEUTICALS, INC. (US) | 2004-11-04 | — | — | WO | claimed |
| US-20040214872-A1 | Pin1-modulating compounds and methods of use thereof | PINTEX PHARMACEUTICALS, INC. | 2004-10-28 | — | — | US | claimed |
| WO-2004028535-A1 | PIN1-MODULATING COMPOUNDS AND METHODS OF USE THEREOF | PINTEX PHARMACEUTICALS, INC. (US) | 2004-04-08 | — | — | WO | claimed |
| US-11912674-B2 | Isoxazole derivatives as nuclear receptor agonists and uses thereof | IL DONG PHARMACEUTICAL CO., LTD. (KR) | 2024-02-27 | — | — | US | disclosed |
| US-20210188790-A1 | ISOXAZOLE DERIVATIVES AS NUCLEAR RECEPTOR AGONISTS AND USES THEREOF | ILDONG PHARMACEUTICAL CO LTD (KR) | 2021-06-24 | — | — | US | disclosed |
| US-10988449-B2 | Isoxazole derivatives as nuclear receptor agonists and uses thereof | IL DONG PHARMACEUTICAL CO., LTD. (KR) | 2021-04-27 | — | — | US | disclosed |
| US-20200115349-A1 | ISOXAZOLE DERIVATIVES AS NUCLEAR RECEPTOR AGONISTS AND USES THEREOF | IL DONG PHARMACEUTICAL CO., LTD. (KR) | 2020-04-16 | — | — | US | disclosed |
| WO-2010104967-A1 | SULFONAMIDE CONTAINING COMPOUNDS AND USES THEREOF | ELIXIR PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| WO-2010104929-A1 | SULFONAMIDE CONTAINING COMPOUNDS AND USES THEREOF | ELIXIR PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| US-7326790-B2 | Diphenylisoxazole compounds and hydro isomers thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2008-02-05 | — | — | US | disclosed |
| EP-1620412-A2 | HETEROCYCLIC COMPOUNDS AND HYDRO ISOMERS THEREOF | Rigel Pharmaceuticals, Inc. (US) | 2006-02-01 | — | — | EP | disclosed |
| EP-1551396-A1 | PIN1-MODULATING COMPOUNDS AND METHODS OF USE THEREOF | Pintex Pharmaceuticals, Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| US-20040254227-A1 | Heterocyclic compounds and hydro isomers thereof | MIDCAP FINANCIAL TRUST | 2004-12-16 | — | — | US | disclosed |
| WO-2004099165-A2 | HETEROCYCLIC COMPOUNDS AND HYDRO ISOMERS THEREOF | RIGEL PHARMACEUTICALS, INC. (US) | 2004-11-18 | — | — | WO | disclosed |
| WO-2004093803-A2 | PHOTOCHEMOTHERAPEUTIC COMPOUNDS FOR USE IN TREATMENT OF PIN1-ASSOCIATED STATES | PINTEX PHARMACEUTICALS, INC. (US) | 2004-11-04 | — | — | WO | disclosed |
| US-20040214872-A1 | Pin1-modulating compounds and methods of use thereof | PINTEX PHARMACEUTICALS, INC. | 2004-10-28 | — | — | US | disclosed |
| WO-2004028535-A1 | PIN1-MODULATING COMPOUNDS AND METHODS OF USE THEREOF | PINTEX PHARMACEUTICALS, INC. (US) | 2004-04-08 | — | — | WO | disclosed |
| US-4027039-A | ADMINISTERING AMINOGUANIDINE, GUANIDINE, OR 1-(SEC-BUTYLIDENEAMINO)GUANIDINE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115349-A1 | ISOXAZOLE DERIVATIVES AS NUCLEAR RECEPTOR AGONISTS AND USES THEREOF | NR1H4, NR1H3, NR1H2 | ALDH1A1 2667/4885KMT2A 4102/4885MEN1 4650/4885 |
| US-20040214872-A1 | Pin1-modulating compounds and methods of use thereof | PIN1, FKBP14, PIN4 | ALDH1A1 4434/4885KMT2A 2626/4885MEN1 3471/4885 |
| US-20040254227-A1 | Heterocyclic compounds and hydro isomers thereof | HAVCR2, PCNA, HCCS | ALDH1A1 491/4885KMT2A 2974/4885MEN1 4165/4885 |
| US-20210188790-A1 | ISOXAZOLE DERIVATIVES AS NUCLEAR RECEPTOR AGONISTS AND USES THEREOF | NR1H4, NR1H3, NR1H2 | ALDH1A1 840/4885KMT2A 4226/4885MEN1 4826/4885 |
| US-10988449-B2 | Isoxazole derivatives as nuclear receptor agonists and uses thereof | NR1H4, NR1H3, NR1H2 | ALDH1A1 2667/4885KMT2A 4102/4885MEN1 4650/4885 |
| US-11912674-B2 | Isoxazole derivatives as nuclear receptor agonists and uses thereof | NR1H4, NR1H3, NR1H2 | ALDH1A1 840/4885KMT2A 4226/4885MEN1 4826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.