SCHEMBL6709012

SCHEMBL6709012

Cn1c(C(=O)Nc2ccc(Cl)cc2-c2noc(=O)[nH]2)cc2ccc(NC(=O)c3ccc(OC(F)(F)F)cc3)cc21

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 9/20 0.45
RXFP1 Q9HBX9 1/20 0.41
THRB P10828 1/20 0.40
TRPV1 Q8NER1 3/20 0.40
MEN1 O00255 1/20 0.39
GALK1 P51570 1/20 0.39
KMT2A Q03164 1/20 0.39
MAPT P10636 1/20 0.38
RARA P10276 1/20 0.38
GCGR P47871 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6710123 0.92 ABL1 (0.43) ABL1THRBTRPV1MEN1GALK1
SCHEMBL6707775 0.90 ABL1 (0.42) ABL1THRBTRPV1MEN1GALK1
SCHEMBL6711769 0.85 GCGR (0.41) ABL1RXFP1THRBTRPV1GCGR
SCHEMBL6713555 0.84 RXFP1 (0.46) RXFP1THRBMEN1KMT2ANPC1
SCHEMBL6711779 0.84 RXFP1 (0.43) RXFP1MEN1KMT2AMAPTNPC1
SCHEMBL6710208 0.83 RXFP1 (0.44) ABL1RXFP1THRBMEN1KMT2A
SCHEMBL6710122 0.83 MEN1 (0.42) RXFP1MEN1KMT2AMAPTNPC1
SCHEMBL6713186 0.82 RXFP1 (0.42) RXFP1
SCHEMBL6708544 0.81 ALDH1A1 (0.47) RXFP1MEN1KMT2AMAPTNPC1
SCHEMBL6711593 0.81 RXFP1 (0.43) RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040142981-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-07-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040142981-A1 Antibacterial benzoic acid derivatives GABRD, PHB1, GABBR1 ABL1 344/4885RXFP1 3836/4885THRB 4472/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.