Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.46 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.42 |
| ▸ | CD74 | P04233 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL671044 | 0.83 | LOXL2 (0.48) | LOXL2CYP4F2CYP4A11ABHD6ROCK2 | |
| SCHEMBL10113453 | 0.83 | HDAC1 (0.53) | LOXL2CYP4F2CYP4A11ABHD6ROCK2 | |
| SCHEMBL22346843 | 0.80 | LOXL2 (0.52) | LOXL2CYP4F2CYP4A11ABHD6ROCK2 | |
| SCHEMBL671067 | 0.78 | CHRM3 (0.53) | LOXL2CYP4F2CYP4A11ABHD6ROCK2 | |
| SCHEMBL13551810 | 0.77 | L3MBTL1 (0.50) | POLBL3MBTL1MEN1ALDH1A1KMT2A | |
| SCHEMBL31773 | 0.75 | LOXL2 (0.52) | LOXL2CYP4F2CYP4A11ABHD6ROCK2 | |
| SCHEMBL669776 | 0.74 | NPC1 (0.43) | LOXL2CYP4F2CYP4A11ABHD6ROCK2 | |
| SCHEMBL1373046 | 0.72 | CYP2D6 (0.67) | LOXL2CYP4F2CYP4A11ABHD6MAPT | |
| SCHEMBL20209837 | 0.72 | CYP2D6 (0.62) | LOXL2CYP4F2CYP4A11ABHD6MAPK10 | |
| SCHEMBL5264931 | 0.72 | CYP4F2 (0.54) | LOXL2CYP4F2CYP4A11MRGPRX4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012024179-A1 | SUBSTITUTED AMIDE DERIVATIVES AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |