SCHEMBL6711546

SCHEMBL6711546

O=C(Cc1ccc(Cl)cc1Cl)Nc1cccc2cc(C(=O)Nc3ccc(Br)cc3-c3nnn[nH]3)[nH]c12

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GALR3 O60755 1/20 0.37
NR2F2 P24468 1/20 0.37
GPR35 Q9HC97 3/20 0.37
NHERF1 O14745 1/20 0.35
MGAM O43451 1/20 0.34
GAA P10253 1/20 0.34
SI P14410 1/20 0.34
MGAM2 Q2M2H8 1/20 0.34
LMNA P02545 3/20 0.34
ALDH1A1 P00352 2/20 0.34
HPGD P15428 2/20 0.34
PARP14 Q460N5 1/20 0.34
TRPV1 Q8NER1 1/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
PLCG2 P16885 1/20 0.33
MAPT P10636 1/20 0.33
APOBEC3G Q9HC16 1/20 0.33
PTK2B Q14289 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6710475 0.95 GALR3 (0.40) GALR3NR2F2NHERF1LMNAALDH1A1
SCHEMBL6714324 0.92 PARP14 (0.42) GPR35NHERF1ALDH1A1PARP14MEN1
SCHEMBL6710366 0.90 PARP14 (0.41) GPR35LMNAALDH1A1PARP14TRPV1
SCHEMBL6713195 0.89 MEN1 (0.42) GPR35LMNAALDH1A1PARP14MEN1
SCHEMBL6707817 0.89 GPR35 (0.35) GPR35LMNAPARP14MEN1KMT2A
SCHEMBL6708676 0.89 PARP14 (0.43) GALR3NR2F2NHERF1GAALMNA
SCHEMBL6707786 0.89 GALR3 (0.36) GALR3NR2F2NHERF1LMNAALDH1A1
SCHEMBL6707957 0.87 PARP14 (0.44) GPR35MGAMGAASIMGAM2
SCHEMBL6707757 0.87 KMT2A (0.49) LMNAALDH1A1HPGDKDM4EMEN1
SCHEMBL6710064 0.86 ALDH1A1 (0.40) GPR35LMNAALDH1A1PARP14MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040142981-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-07-22 US disclosed
WO-2004018461-A2 ANTIBACTERIAL BENZOIC ACID DERIVATIVES PHARMACIA & UPJOHN COMPANY LLC (US) 2004-03-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040142981-A1 Antibacterial benzoic acid derivatives GABRD, PHB1, GABBR1 GALR3 4874/4885NR2F2 1512/4885GPR35 2928/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.