Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | DDO | Q99489 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31059216 | 0.76 | KDR (0.53) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL2430291 | 0.76 | CHEK1 (0.61) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL29370693 | 0.73 | KDR (1.00) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL5076094 | 0.73 | KDR (1.00) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL19290 | 0.71 | KDR (0.61) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL1618522 | 0.70 | KDR (0.64) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL374022 | 0.70 | RAB9A (0.74) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL29631691 | 0.70 | RAB9A (0.74) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL8086286 | 0.69 | KDR (0.58) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL8788050 | 0.69 | IL4I1 (0.53) | KDRCHEK1RAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040198981-A1 | Tricyclic dihydroquinoline derivatives,method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2004-10-07 | — | — | US | disclosed |
| US-20040180917-A1 | Novel tricyclic dihydro-quinoline derivatives, method for preparing same and pharmaceutical compositions containing the same | HUSSON HENRI-PHILIPPE (FR) | 2004-09-16 | — | — | US | disclosed |
| EP-1103554-B9 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | SERVIER LAB (FR) | 2003-12-17 | — | — | EP | disclosed |
| US-6548515-B1 | Use as anticancer agents | LES LABORATORIES SERVIER (FR) | 2003-04-15 | — | — | US | disclosed |
| EP-1103554-B1 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | SERVIER LAB (FR) | 2003-03-12 | — | — | EP | disclosed |
| EP-1103554-A1 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180917-A1 | Novel tricyclic dihydro-quinoline derivatives, method for preparing same and pharmaceutical compositions containing the same | SCN11A, CYP4A11, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | KDR 3944/4885CHEK1 2542/4885RAB9A 182/4885 |
| US-20040198981-A1 | Tricyclic dihydroquinoline derivatives,method for preparing same and pharmaceutical compositions containing same | CYP2C8, CYP2D6, UGT1A8 | KDR 2777/4885CHEK1 3176/4885RAB9A 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.