Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.54 |
| ▸ | DRD2 | P14416 | 6/20 | 0.54 |
| ▸ | DRD3 | P35462 | 6/20 | 0.54 |
| ▸ | DRD4 | P21917 | 4/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | HTR7 | P34969 | 3/20 | 0.54 |
| ▸ | HTR6 | P50406 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6714260 | 0.88 | HTR1A (0.55) | HTR1ADRD2DRD3HTR2AHTR7 | |
| SCHEMBL9481428 | 0.81 | HTR1A (0.60) | HTR1ADRD2DRD3DRD4HTR2A | |
| SCHEMBL6714591 | 0.81 | HRH4 (0.57) | HTR1ADRD2DRD3DRD4ADRA1D | |
| SCHEMBL6711645 | 0.78 | ALDH1A1 (0.48) | HTR1ADRD2DRD3HTR2AHTR7 | |
| SCHEMBL6719642 | 0.78 | HTR3E (0.54) | HTR1ADRD2DRD3DRD4HTR2A | |
| SCHEMBL9400863 | 0.76 | HTR1A (0.68) | HTR1ADRD2DRD3DRD4HTR2A | |
| SCHEMBL9480366 | 0.76 | HTR1A (0.68) | HTR1ADRD2DRD3DRD4HTR2A | |
| Hydrochloric Acid SCHEMBL6712709 | 0.76 | HTR1A (0.54) | HTR1ADRD2DRD3HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL6719032 | 0.74 | DRD3 (0.50) | HTR1ADRD2DRD3DRD4HTR2A | |
| SCHEMBL9400845 | 0.74 | HTR1A (0.87) | HTR1ADRD2DRD3DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040138203-A1 | Bicyclic lactams and sulfonamides with 5-ht1a -affinity and use thereof for preventing and treating cerebral ischaemia | STEINER GERD | 2004-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138203-A1 | Bicyclic lactams and sulfonamides with 5-ht1a -affinity and use thereof for preventing and treating cerebral ischaemia | HTR1A, HTR5A, HTR2C | HTR1A 1/4885DRD2 83/4885DRD3 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.