Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.42 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.42 |
| ▸ | FASN | P49327 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6508734 | 0.81 | KDM4E (0.59) | NPC1RAB9AKDM4EALDH1A1PKM | |
| SCHEMBL6711707 | 0.79 | MLYCD (0.47) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27570619 | 0.76 | CDK2 (0.38) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL7257113 | 0.76 | CDK2 (0.38) | ALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL27572548 | 0.76 | CDK2 (0.38) | ALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL27574287 | 0.75 | CCNE1 (0.37) | ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL6710898 | 0.75 | MLYCD (0.38) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL27574281 | 0.74 | CDK2 (0.38) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL27551074 | 0.74 | CDK2 (0.38) | ALDH1A1SMN1; SMN2LMNACHEK2GAA | |
| SCHEMBL6287985 | 0.73 | HPSE (0.66) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040157827-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | PEVARELLO PAOLO (IT) | 2004-08-12 | — | — | US | disclosed |
| US-20030187040-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2003-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187040-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | UCK2, ULK3, CDK2 | NPC1 2685/4885RAB9A 2674/4885KDM4E 2087/4885 |
| US-20040157827-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | UCK2, ULK3, CDK2 | NPC1 2685/4885RAB9A 2674/4885KDM4E 2087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.