⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23844 | 0.78 | MAPT (0.55) | — | |
| SCHEMBL194246 | 0.76 | MAPT (0.39) | — | |
| SCHEMBL11227486 | 0.76 | TDP1 (0.50) | — | |
| SCHEMBL2401626 | 0.74 | BCHE (0.31) | — | |
| SCHEMBL193961 | 0.71 | KMT2A (0.34) | — | |
| SCHEMBL10674984 | 0.70 | — | — | |
| SCHEMBL15987437 | 0.70 | KDM4E (0.50) | — | |
| SCHEMBL8707994 | 0.69 | MAOA (0.31) | — | |
| SCHEMBL8719387 | 0.69 | KMT2A (0.47) | — | |
| SCHEMBL2478096 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040101523-A1 | Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension | G.D. SEARLE & CO. | 2004-05-27 | — | — | US | claimed |
| US-20030220521-A1 | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension | G.D. SEARLE & CO. | 2003-11-27 | — | — | US | claimed |
| EP-0484437-A4 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | SEARLE & CO (US) | 1994-06-01 | — | — | EP | claimed |
| EP-0484437-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. Searle & Co. (US) | 1992-05-13 | — | — | EP | claimed |
| WO-1992001667-A1 | RENAL-SELECTIVE PRODRUGS FOR CONTROL OF RENAL SYMPATHETIC NERVE ACTIVITY IN THE TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1992-02-06 | — | — | WO | claimed |
| WO-1991001724-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1991-02-21 | — | — | WO | claimed |
| US-4775747-A | PIGMENTS FOR POLYMERS | CIBA-GEIGY CORPORATION (US) | 1988-10-04 | — | — | US | claimed |
| US-20230310358-A1 | Compositions And Methods For Treating Autism | YAMO PHARMACEUTICALS LLC (US) | 2023-10-05 | — | — | US | disclosed |
| CN-114901272-A | Sustained release preparation | 霍夫曼技术有限责任公司 | 2022-08-12 | — | — | CN | disclosed |
| US-20220211650-A1 | SUSTAINED RELEASE FORMULATIONS | HOFFMAN TECHNOLOGIES LLC | 2022-07-07 | — | — | US | disclosed |
| EP-3955910-A1 | SUSTAINED RELEASE FORMULATIONS | Hoffman Technologies LLC. (US) | 2022-02-23 | — | — | EP | disclosed |
| US-20210338619-A1 | COMPOSITIONS AND METHODS FOR TREATING AUTISM | YAMO PHARMACEUTICALS LLC | 2021-11-04 | — | — | US | disclosed |
| EP-3823626-A1 | COMPOSITIONS AND METHODS FOR TREATING AUTISM | Yamo Pharmaceuticals LLC (US) | 2021-05-26 | — | — | EP | disclosed |
| EP-0092830-A2 | Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and their application | CIBA-GEIGY AG (CH) | 1983-11-02 | — | — | EP | disclosed |
| US-4271187-A | Substituted phenyl alanine antihypertensive agents | MERCK & CO., INC. (US) | 1981-06-02 | — | — | US | disclosed |
| US-4206216-A | Antihypertensive N-heterocyclicalanines | MERCK & CO., INC. (US) | 1980-06-03 | — | — | US | disclosed |
| US-4160835-A | Antihypertensive compositions containing an arylsubstituted alanine and a phenyl hydrazinopropionic acid | MERCK & CO., INC. (US) | 1979-07-10 | — | — | US | disclosed |
| US-4156734-A | Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid | MERCK & CO., INC. (US) | 1979-05-29 | — | — | US | disclosed |
| US-4153715-A | Indolyl amino acids useful as antihypertensive agents | MERCK & CO., INC. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4065572-A | Amino acids and esters thereof useful as antihypertensive agents | MERCK & CO., INC. (US) | 1977-12-27 | — | — | US | disclosed |