Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | SPHK1 | Q9NYA1 | 9/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.56 |
| ▸ | MGLL | Q99685 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15924542 | 0.89 | SPHK1 (0.63) | HPGDSPHK1SPHK2MGLLLMNA | |
| SCHEMBL15923369 | 0.89 | SPHK1 (0.63) | HPGDSPHK1SPHK2MGLLLMNA | |
| SCHEMBL18978543 | 0.86 | ALDH1A1 (0.62) | HPGDSPHK1KMT2ASPHK2ALDH1A1 | |
| SCHEMBL20922362 | 0.84 | L3MBTL3 (0.67) | KMT2AALDH1A1 | |
| SCHEMBL8279585 | 0.83 | ACHE (0.66) | HPGDKMT2AACHEMGLLALDH1A1 | |
| SCHEMBL26553934 | 0.82 | TPSAB1 (0.54) | HPGDSPHK1KMT2ASPHK2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL25402315 | 0.81 | HPGD (0.55) | HPGDSPHK1KMT2ASPHK2ALDH1A1 | |
| SCHEMBL3920090 | 0.81 | HRH3 (0.60) | SPHK1SPHK2ALDH1A1 | |
| SCHEMBL10722678 | 0.81 | ACHE (0.82) | HPGDKMT2AACHEALDH1A1LMNA | |
| SCHEMBL4378289 | 0.80 | DRD2 (0.64) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | disclosed |